ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2016
The polymorphism in miR-25 attenuated the oncogenic function in gastric cancer.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Article
- Overexpression of miR-25 is associated with progression and poor prognosis of cholangiocarcinoma.Experimental and therapeutic medicine · 2019Article
- Expression of miR-124 in gastric adenocarcinoma and the effect on proliferation and invasion of gastric adenocarcinoma SCG-7901 cells.Oncology letters · 2019Article
- Clinical significance of serum miR-25 as a diagnostic and prognostic biomarker in human gastric cancer.Cancer biomarkers : section A of Disease markers · 2019Article
- A myriad of roles of miR-25 in health and disease.Oncotarget · 2018Review
- Association between the SNPs of theJournal of Cancer · 2018Article
- Decreased TOB1 expression and increased phosphorylation of nuclear TOB1 promotes gastric cancer.Oncotarget · 2017Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
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Abstract
miR-25 was identified as an essential oncogene by promoting the growth and metastasis through TOB1 in gastric cancer (GC). The function of the single nucleotide polymorphism (SNP) located in the mature region of miR-25 (rs41274221) has not been investigated. In this study, we aimed to explore the involvement of rs41274221 in miR-25 in gastric cancer. We found that SNP rs41274221 in miR-25 was participated in the occurrence of GC by acting as a tumor protective factor associating with the tumor growth and metastasis. Besides, further investigation found that upregulation of miR-25 with AA genotype could attenuate the proliferation and invasion of tumor cells caused by wild-type miR-25. The dual-luciferase reporter assay also confirmed that miR-25 harbored the A allele which caused an incapacitation of binding at the TOB1. In conclusion, rs41274221 in miR-25 was a subgroup which may protect the patients from further growth and metastasis of gastric cancer and might serve as a novel biomarker for the disease.
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