ArticleAmerican journal of respiratory and critical care medicine2016
Rhinovirus Detection in Symptomatic and Asymptomatic Children: Value of Host Transcriptome Analysis.
Article in American journal of respiratory and critical care medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.
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Who cites it
65 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.
- A consensus immune dysregulation framework for sepsis and critical illnesses.Nature medicine · 2025Guideline
- Prior upregulation of interferon pathways in the nasopharynx impacts viral shedding following live attenuated influenza vaccine challenge in children.Cell reports. Medicine · 2021Trial
- The Feasibility of Host Transcriptome Profiling as a Diagnostic Tool for Microbial Etiology in Childhood Cancer Patients with Febrile Neutropenia.International journal of molecular sciences · 2020Trial
- Nasal microbiota clusters associate with inflammatory response, viral load, and symptom severity in experimental rhinovirus challenge.Scientific reports · 2018Trial
- Clinical significance of human rhino-/enterovirus co-detection in pediatric Mycoplasma pneumoniae infections.Infection · 2026Article
- Neonatal Bloodstream Infections: A Narrative Review on Diagnostic and Therapeutic Challenges and Prospects in Developing Countries.Health science reports · 2026Article
- Age-Related Asymptomatic Rhinovirus Infections Contribute to the Sustained Prevalence in Adults and Are Not Mitigated by Nonpharmaceutical Interventions.Influenza and other respiratory viruses · 2026Article
- Incidence, viral etiology, and risk factors of wheezing in children under two years of age: findings from a low-income urban community in Dhaka, Bangladesh.BMC pulmonary medicine · 2026Article
- Mycoplasma pneumoniae re-emergence: clinical features revisited.European journal of pediatrics · 2025Article
- [Epidemiological characteristics of human metapneumovirus and risk factors for severe pneumonia in hospitalized children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Article
- SARS-CoV-2 induced immune perturbations in infants vary with disease severity and differ from adults' responses.Nature communications · 2025Article
- Unveiling the prevalence and impact of silent rhinovirus infection in chronic rhinosinusitis with nasal polyps.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2025Article
- Epigenetic training of human bronchial epithelium cells by repeated rhinovirus infections.Allergy · 2024Article
- A T-Cell-Derived 3-Gene Signature Distinguishes SARS-CoV-2 from Common Respiratory Viruses.Viruses · 2024Article
- Systems immunology of transcriptional responses to viral infection identifies conserved antiviral pathways across macaques and humans.Cell reports · 2024Article
- Article
- Integrated host/microbe metagenomics enables accurate lower respiratory tract infection diagnosis in critically ill children.The Journal of clinical investigation · 2023Article
- A robust host-response-based signature distinguishes bacterial and viral infections across diverse global populations.Cell reports. Medicine · 2022Article
- Detection of group A streptococcus in children with confirmed viral pharyngitis and antiviral host response.European journal of pediatrics · 2022Observational
- Integrating central nervous system metagenomics and host response for diagnosis of tuberculosis meningitis and its mimics.Nature communications · 2022Article
5 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors at 5 institutions in 4 countries.
Funding
Abstract
rationaleRhinoviruses (RVs) are a major cause of symptomatic respiratory tract infection in all age groups. However, RVs can frequently be detected in asymptomatic individuals.
objectivesTo evaluate the ability of host transcriptional profiling to differentiate between symptomatic RV infection and incidental detection in children.
methodsPreviously healthy children younger than 2 years old (n = 151) were enrolled at four study sites and classified into four clinical groups: RV- healthy control subjects (n = 37), RV+ asymptomatic subjects (n = 14), RV+ outpatients (n = 30), and RV+ inpatients (n = 70). Host responses were analyzed using whole-blood RNA transcriptional profiles. MEASUREMENTS AND MAIN
resultsRV infection induced a robust transcriptional signature, which was validated in three independent cohorts and by quantitative real-time polymerase chain reaction with high prediction accuracy. The immune profile of symptomatic RV infection was characterized by overexpression of innate immunity and underexpression of adaptive immunity genes, whereas negligible changes were observed in asymptomatic RV+ subjects. Unsupervised hierarchical clustering identified two main clusters of subjects. The first included 93% of healthy control subjects and 100% of asymptomatic RV+ subjects, and the second comprised 98% of RV+ inpatients and 88% of RV+ outpatients. Genomic scores of healthy control subjects and asymptomatic RV+ children were similar and significantly lower than those of RV+ inpatients and outpatients (P < 0.0001).
conclusionsSymptomatic RV infection induced a robust and reproducible transcriptional signature, whereas identification of RV in asymptomatic children was not associated with significant systemic transcriptional immune responses. Transcriptional profiling represents a useful tool to discriminate between active infection and incidental virus detection.
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