ArticlePloS one2015
A Comprehensive MicroRNA Expression Profile Related to Hypoxia Adaptation in the Tibetan Pig.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- circRNA-Associated ceRNA Regulatory Networks in Cardiac Responses to High-Altitude Hypoxia in Tibetan Pigs (International journal of molecular sciences · 2026Article
- Comprehensive transcriptome analysis reveals MSTRG.19853.1/ssc-miR-361-3p/NPPA axis is related to hypoxic adaptation in Tibetan pigs.BMC genomics · 2025Article
- Transcriptomic and Metabolomic Insights into Age-Related Changes in Lung Tissue of Yaks Under Highland Stress.International journal of molecular sciences · 2024Article
- Screening of functional genes for hypoxia adaptation in Tibetan pigs by combined genome resequencing and transcriptome analysis.Frontiers in veterinary science · 2024Article
- Comparison of the gut microbiota and metabolites between Diannan small ear pigs and Diqing Tibetan pigs.Frontiers in microbiology · 2023Article
- StandardizedFrontiers in pharmacology · 2023Article
- Remodeling of the microbiota improves the environmental adaptability and disease resistance in Tibetan pigs.Frontiers in microbiology · 2022Article
- Physiology and Transcriptomics Analysis Reveal the Contribution of Lungs on High-Altitude Hypoxia Adaptation in Tibetan Sheep.Frontiers in physiology · 2022Article
- The Expression Regulatory Network in the Lung Tissue of Tibetan Pigs Provides Insight Into Hypoxia-Sensitive Pathways in High-Altitude Hypoxia.Frontiers in genetics · 2021Article
- Population Genetic Analysis of Ten Geographically Isolated Tibetan Pig Populations.Animals : an open access journal from MDPI · 2020Article
- Analysis of Transcriptome and miRNAome in the Muscle of Bamei Pigs at Different Developmental Stages.Animals : an open access journal from MDPI · 2020Article
- Transcriptional Regulation ofGenes · 2020Article
- MicroRNA expression profile is altered in the upper airway skeletal muscle tissue of patients with obstructive sleep apnea-hypopnea syndrome.The Journal of international medical research · 2019Article
- Comparative proteomic analysis of Tibetan pig spermatozoa at high and low altitudes.BMC genomics · 2019Article
- Probing the Effect of Glucose on the Activity and Stability of β-Glucosidase: An All-Atom Molecular Dynamics Simulation Investigation.ACS omega · 2019Article
- Genomic analysis reveals variant association with high altitude adaptation in native chickens.Scientific reports · 2019Article
- Genome-wide DNA methylation profiles in Tibetan and Yorkshire pigs under high-altitude hypoxia.Journal of animal science and biotechnology · 2019Article
- Role of miRNAs in hypoxia-related disorders.Journal of biosciences · 2018Review
- Comparison of stomach microRNA transcriptomes of Tibetan and Yorkshire pigs by deep sequencing.Genes & genomics · 2018Article
- Whole-genome de novo sequencing reveals unique genes that contributed to the adaptive evolution of the Mikado pheasant.GigaScience · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tibetan pigs live between 2500 and 4300 m above sea level on the Tibetan Plateau, and are better adapted to hypoxia than lowland pigs. MicroRNAs (miRNAs) are involved in a wide variety of cellular processes; however, their regulatory role in hypoxia adaptation remains unclear. In this study, miRNA-seq was used to identify differentially expressed miRNAs (DE miRNAs) in the cardiac muscle of Tibetan and Yorkshire pigs, which were both raised in high elevation environments. We obtained 108 M clean reads and 372 unique miRNAs, which included 210 known porcine miRNAs, 136 conserved in other mammals, and 26 novel pre-miRNAs. In addition, 20 DE miRNAs, including 10 up-regulated and 10 down-regulated miRNAs, were also found after comparison between Tibetan and Yorkshire pigs. We predicted miRNA targets based on differential expression and abundance in the two populations. Furthermore, the results of a Kyoto Encyclopedia of Genes and Genomes pathway analysis suggested that DE miRNAs in Tibetan and Yorkshire pigs are involved in hypoxia-related signaling pathways such as the mitogen-activated protein kinase, which is the mechanistic target of rapamycin, and the vascular endothelial growth factor, as well as cancer-related signaling pathways. Five DE miRNAs were randomly selected to validate the results of miRNA-seq using real-time polymerase chain reaction, and the results corresponded to those from the miRNA-seq, confirming that deep-sequencing methods are feasible and efficient. In our study, we identified various previously unknown hypoxia-related miRNAs in pigs, and the data obtained suggest that hypoxia-related miRNA expression patterns are significantly altered in the Tibetan pig compared to other species. Therefore, DE miRNAs may play an important role in organisms that have adapted to hypoxic environments.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.