ArticlePediatric research2016
A novel method for assessing cerebral autoregulation in preterm infants using transfer function analysis.
Article in Pediatric research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Cerebrovascular autoregulation and preterm brain injury: a systematic review and meta-analysis.Pediatric research · 2025Pooled it
- Effects of different surfactant administrations on cerebral autoregulation in preterm infants with respiratory distress syndrome.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2016Trial
- Impact of posthemorrhagic ventricular dilatation on cerebral oxygenation in preterm infants with intraventricular hemorrhage.Pediatric research · 2026Article
- Cerebral autoregulation in pediatric and neonatal intensive care: A scoping review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Near-infrared spectroscopy monitoring of neonatal cerebrovascular reactivity: where are we now?Pediatric research · 2024Review
- Evaluation of the Hypotensive Preterm Infant: Evidence-Based Practice at the Bedside?Children (Basel, Switzerland) · 2023Review
- Diffuse correlation spectroscopy blood flow monitoring for intraventricular hemorrhage vulnerability in extremely low gestational age newborns.Scientific reports · 2022Article
- Cerebral saturation reflects anterior cerebral artery flow parameters by Doppler ultrasound in the extremely premature newborn.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Real-Time Evaluation of Cerebral Autoregulation Based on Near-Infrared Spectroscopy to Predict Clinical Outcome after Bypass Surgery in Moyamoya Disease.BioMed research international · 2022Article
- Cerebral Oxygenation in Preterm Infants Developing Cerebral Lesions.Frontiers in pediatrics · 2022Article
- Regulation of the Cerebral Circulation During Development.Comprehensive Physiology · 2021Article
- Neonatal NIRS monitoring: recommendations for data capture and review of analytics.Journal of perinatology : official journal of the California Perinatal Association · 2021Review
- The hidden consequence of intraventricular hemorrhage: persistent cerebral desaturation after IVH in preterm infants.Pediatric research · 2021Article
- Delayed cord clamping is associated with improved dynamic cerebral autoregulation and decreased incidence of intraventricular hemorrhage in preterm infants.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Early hypoxemia burden is strongly associated with severe intracranial hemorrhage in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
- Cerebral autoregulation and activity after propofol for endotracheal intubation in preterm neonates.Pediatric research · 2018Article
- Delayed cord clamping and inotrope use in preterm infants.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2018Article
- Cerebral oxygen saturation and peripheral perfusion in the extremely premature infant with intraventricular and/or pulmonary haemorrhage early in life.Scientific reports · 2018Observational
- Cerebral oxygenation during umbilical arterial blood sampling in very low birth weight neonates.Journal of perinatology : official journal of the California Perinatal Association · 2018Observational
- Measuring Near-Infrared Spectroscopy Derived Cerebral Autoregulation in Neonates: From Research Tool Toward Bedside Multimodal Monitoring.Frontiers in pediatrics · 2018Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAutoregulatory dysfunction is an important contributor to brain injury in premature infants, particularly intraventricular hemorrhage (IVH). The autoregulatory system acts as a filter that dampens the systemic blood flow to follow a normal cerebral perfusion profile.
methodsSimultaneous arterial blood pressure and cerebral near-infrared spectroscopy (NIRS) data were collected from infants born before 28 wk estimated gestational age. The resulting data were preprocessed and then divided into nonoverlapping 20-min epochs. The transfer function estimate was calculated to determine dampening ability.
resultsSixty-two infants were prospectively recruited with a mean estimated gestational age of 25.4 ± 1.3 wk and birth weight of 832 ± 199 g. 67% were male, 24/62 had IVH, 17/62 received dopamine, 47/62 had antenatal steroid exposure, and 22/62 received fentanyl.Advancing estimated gestational age and birth weight z-score predicted stronger dampening while African-American race and IVH of any grade predicted weaker dampening.
conclusionThis preliminary report suggests an impairment in dampening ability associated with immaturity, decreased birth weight z-score, and African-American race. Decreased dampening is also associated with IVH, although these results cannot distinguish between decreased dampening as an antecedent or sequela of IVH. These observations should be studied in a larger sample.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.