ArticleMedical principles and practice : international journal of the Kuwait University, Health Science Centre2016
Breast Cancer Induced by X-Ray Mammography Screening? A Review Based on Recent Understanding of Low-Dose Radiobiology.
Article in Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 77 citations in OpenAlex.
- Investigating the Average Glandular Dose and Exposure Parameters in Mammography Based on Compressed Breast Thickness and Imaging Projection: A Single-Centre Study in Jeddah, Saudi Arabia.Healthcare (Basel, Switzerland) · 2026Article
- Clinical Evaluation of Susceptibility-weighted MR Imaging for the Detection of Intramammary Micro- and Macrocalcifications in 70 Female Patients at 1.5T.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026Article
- Anatomy-guided breast segmentation in thermograms using a multiscale UNet hybrid framework.BMC medical imaging · 2025Article
- In-vitro Detection of Intramammary-like Macrocalcifications Using Susceptibility-weighted MR Imaging Techniques at 1.5T.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025Article
- The Impact of Automatic Exposure Control Technology on the In Vivo Radiation Dose in Digital Mammography: A Comparison Between Different Systems and Target/Filter Combinations.Diagnostics (Basel, Switzerland) · 2025Article
- Development of Iron Oxide Nanochains as a Sensitive Magnetic Particle Imaging Tracer for Cancer Detection.ACS applied materials & interfaces · 2025Article
- Effect of X-Ray Energy on the Quantitative Yield of γH2AX and 53BP1 Foci in Human Mesenchymal Stem Cells.Bulletin of experimental biology and medicine · 2025Article
- Swarm learning with weak supervision enables automatic breast cancer detection in magnetic resonance imaging.Communications medicine · 2025Article
- LightweightUNet: Multimodal Deep Learning with GAN-Augmented Imaging Data for Efficient Breast Cancer Detection.Bioengineering (Basel, Switzerland) · 2025Article
- U structured network with three encoding paths for breast tumor segmentation.Scientific reports · 2023Article
- Relative biological effectiveness of low-energy X-rays (25 kV) in mutant p53 cancer cells.Radiation and environmental biophysics · 2023Article
- ERN GENTURIS tumour surveillance guidelines for individuals with neurofibromatosis type 1.EClinicalMedicine · 2023Review
- Local Diagnostic Reference Levels for Full-Field Digital Mammography and Digital Breast Tomosynthesis in a Tertiary Hospital in Malaysia.Healthcare (Basel, Switzerland) · 2022Article
- Quality of Informed Consent in Mammography Screening-The Polish Experience.International journal of environmental research and public health · 2022Article
- Digital breast tomosynthesis-based peritumoral radiomics approaches in the differentiation of benign and malignant breast lesions.Diagnostic and interventional radiology (Ankara, Turkey) · 2022Article
- Breast Tumour Classification Using Ultrasound Elastography with Machine Learning: A Systematic Scoping Review.Cancers · 2022Article
- PARP Inhibition and Beyond in BRCA-Associated Breast Cancer in Women: A State-Of-The-Art Summary of Preclinical Research on Risk Reduction and Clinical Benefits.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2022Review
- Cancer incidence after childhood irradiation for tinea capitis in a Portuguese cohort.The British journal of radiology · 2020Article
- Review
- Investigation of Exposure Factors for Various Breast Composition and Thicknesses in Digital Screening Mammography Related to Breast Dose.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2018Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Screening mammography offers the possibility of discovering malignant diseases at an early stage, which is consequently treated early, thereby reducing the mortality rate. However, ionizing radiation as used in low-dose X-ray mammography may be associated with a risk of radiation-induced carcinogenesis. In the context of the harmful effects of ionizing radiation, this article reviewed novel radiobiological data and provided a simulation of the relative incidence of radiation-induced breast cancer due to screening against a background baseline incidence in a population of 100,000 individuals. The use of modern digital mammographic technology was assumed, giving rise to a glandular dose of 2.5 mGy from a 2-view per breast image. Assuming no latency time, this led to a ratio of induced incidence rate over baseline incidence rate of about 1.6‰ for biennial screening in women aged 50-74 years, although it cannot be excluded that the dose and dose rate effectiveness factor values relying on new radiobiological insights may lower this number to about 0.7‰. This carcinogenic risk is considered small in relation to the potential beneficial effects of screening, especially as latency time was not taken into consideration. However, individuals who are known to be carriers of risk-increasing genetic variations and/or have an inherited disposition of breast cancer should avoid ionizing radiation as much as possible and should be referred to ultrasound or magnetic resonance imaging. In addition, a significant, but difficult to quantify, risk of cancer is present for individuals who suffer from hypersusceptibility to ionizing radiation.
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