ReviewNatural product reports2016
Recent advances in the biosynthesis of unusual polyketide synthase substrates.
Review in Natural product reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed.
- Sustainable Biocatalytic Cascades: A Versatile Tool in the Synthesis of Natural Products With Therapeutic Potential.Chembiochem : a European journal of chemical biology · 2026Review
- Strepactones A-C: Unprecedented 6/8/5-Tricyclic Polyketides and Their Derivative from a Coral Reef-DerivedMarine drugs · 2026Article
- Article
- Plug-and-play engineering of modular polyketide synthases.Nature chemical biology · 2025Article
- Impact of heterologous expression of Cannabis sativa tetraketide synthase on Phaeodactylum tricornutum metabolic profile.Biotechnology for biofuels and bioproducts · 2025Article
- Discovery and Derivatization of Tridecaptin Antibiotics with Altered Host Specificity and Enhanced Bioactivity.ACS chemical biology · 2024Article
- Genomic insights into an endophyticFrontiers in microbiology · 2024Article
- Characterization of three succinyl-CoA acyltransferases involved in polyketide chain assembly.Applied microbiology and biotechnology · 2023Article
- Engineering site-selective incorporation of fluorine into polyketides.Nature chemical biology · 2022Article
- Bifurcation drives the evolution of assembly-line biosynthesis.Nature communications · 2022Article
- Precursor Quantitation Methods for Next Generation Food Production.Frontiers in bioengineering and biotechnology · 2022Review
- Saccharomyces cerevisiae as host for the recombinant production of polyketides and nonribosomal peptides.Microbial cell factories · 2021Review
- Initiating polyketide biosynthesis by on-line methyl esterification.Nature communications · 2021Article
- A Straightforward Synthesis of Polyketides via Ester Dienolate Matteson Homologation.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Accessory Chromosome-Acquired Secondary Metabolism in Plant Pathogenic Fungi: The Evolution of Biotrophs Into Host-Specific Pathogens.Frontiers in microbiology · 2021Review
- Interfacial plasticity facilitates high reaction rate ofProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Site directed mutagenesis as a precision tool to enable synthetic biology with engineered modular polyketide synthases.Synthetic and systems biotechnology · 2020Review
- Unraveling the iterative type I polyketide synthases hidden inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- The Mosaic Architecture of NRPS-PKS in the Arbuscular Mycorrhizal FungusFrontiers in microbiology · 2020Article
- The Amipurimycin and Miharamycin Biosynthetic Gene Clusters: Unraveling the Origins of 2-Aminopurinyl Peptidyl Nucleoside Antibiotics.Journal of the American Chemical Society · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
This highlight provides an overview of recent advances in understanding the diversity of polyketide synthase (PKS) substrate building blocks. Substrates functioning as starter units and extender units contribute significantly to the chemical complexity and structural diversity exhibited by this class of natural products. This article complements and extends upon the current comprehensive reviews that have been published on these two topics (Moore and Hertweck, Nat. Prod. Rep., 2002, 19, 70; Chan et al., Nat. Prod. Rep., 2009, 1, 90; Wilson and Moore, Nat. Prod. Rep., 2012, 29, 72).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.