ArticlePloS one2015
A Novel Procedure for Rapid Imaging of Adult Mouse Brains with MicroCT Using Iodine-Based Contrast.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- High-resolution hybrid micro-CT imaging pipeline for mouse brain region segmentation and volumetric morphometry.PloS one · 2024Article
- Revealing the three-dimensional murine brain microstructure by contrast-enhanced computed tomography.Frontiers in neuroscience · 2023Article
- High-resolution micro-CT for 3D infarct characterization and segmentation in mice stroke models.Scientific reports · 2022Article
- Morphology of the murine choroid plexus: Attachment regions and spatial relation to the subarachnoid space.Frontiers in neuroanatomy · 2022Article
- SlicerMorph: An open and extensible platform to retrieve, visualize and analyze 3D morphology.Methods in ecology and evolution · 2021Article
- Multiscale imaging of the rat brain using an integrated diceCT and histology workflow.Brain structure & function · 2021Article
- Contrast enhanced X-ray computed tomography imaging of amyloid plaques in Alzheimer disease rat model on lab based micro CT system.Scientific reports · 2021Article
- Scalable method for micro-CT analysis enables large scale quantitative characterization of brain lesions and implants.Scientific reports · 2020Article
- ViceCT and whiceCT for simultaneous high-resolution visualization of craniofacial, brain and ventricular anatomy from micro-computed tomography.Scientific reports · 2020Article
- Imaging of Mouse Brain Fixated in Ethanol in Micro-CT.BioMed research international · 2019Article
- Hydrogel-Tissue Chemistry: Principles and Applications.Annual review of biophysics · 2018Review
- A micro-CT-based method for quantitative brain lesion characterization and electrode localization.Scientific reports · 2018Article
- Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model.Journal of visualized experiments : JoVE · 2017Article
- Using clinically acquired MRI to construct age-specific ADC atlases: Quantifying spatiotemporal ADC changes from birth to 6-year old.Human brain mapping · 2017Article
- Future of the Renal Biopsy: Time to Change the Conventional Modality Using Nanotechnology.International journal of biomedical imaging · 2017Review
- Brain Vascular Imaging Techniques.International journal of molecular sciences · 2016Review
- Micro-computed tomography in murine models of cerebral cavernous malformations as a paradigm for brain disease.Journal of neuroscience methods · 2016Article
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2 authors.
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Abstract
High-resolution Magnetic Resonance Imaging (MRI) has been the primary modality for obtaining 3D cross-sectional anatomical information in animals for soft tissue, particularly brain. However, costs associated with MRI can be considerably high for large phenotypic screens for gross differences in the structure of the brain due to pathology and/or experimental manipulations. MicroCT (mCT), especially benchtop mCT, is becoming a common laboratory equipment with throughput rates equal or faster than any form of high-resolution MRI at lower costs. Here we explore adapting previously developed contrast based mCT to image adult mouse brains in-situ. We show that 2% weight per volume (w/v) iodine-potassium iodide solution can be successfully used to image adult mouse brains within 48 hours post-mortem when a structural support matrix is used. We demonstrate that hydrogel can be effectively used as a perfusant which limits the tissue shrinkage due to iodine.
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