ArticleJournal of affective disorders2016
Cortical abnormalities and association with symptom dimensions across the depressive spectrum.
Article in Journal of affective disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Meta-analysis of cortical thickness abnormalities in medication-free patients with major depressive disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Pooled it
- Exercise effects on depression: Possible neural mechanisms.General hospital psychiatry · 2017Pooled it
- The cross-site reproducibility of MRI morphometric phenotypes in psychiatric disorders.Nature neuroscience · 2026Article
- Latent Profile Analysis of Childhood Maltreatment and Neural Markers in Depression.JAMA network open · 2025Article
- Multimodal neuroimaging exploration of the mechanisms of sleep quality deterioration after SARS-CoV-2 Omicron infection.BMC medicine · 2024Article
- Transdiagnostic symptom of depression and anxiety associated with reduced gray matter volume in prefrontal cortex.Psychiatry research. Neuroimaging · 2024Article
- Multi-site benchmark classification of major depressive disorder using machine learning on cortical and subcortical measures.Scientific reports · 2024Article
- Gestational iron deficiency affects the ratio between interneuron subtypes in the postnatal cerebral cortex in mice.Development (Cambridge, England) · 2023Article
- Inflammatory bowel diseases, interleukin-6 and interleukin-6 receptor subunit alpha in causal association with cerebral cortical structure: a Mendelian randomization analysis.Frontiers in immunology · 2023Article
- Sex differences of brain cortical structure in major depressive disorder.Psychoradiology · 2023Article
- Rostral anterior cingulate connectivity in older adults with subthreshold depressive symptoms: A preliminary study.Aging brain · 2023Article
- Sex-specific alterations of cortical morphometry in treatment-naïve patients with major depressive disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Gray-Matter Morphometry of Internalizing-Symptom Dimensions During Adolescence.Clinical psychological science : a journal of the Association for Psychological Science · 2022Article
- Orbitofrontal and Cingulate Thickness Asymmetry Associated with Depressive Symptom Dimensions.Cognitive, affective & behavioral neuroscience · 2021Article
- Subclinical Anxiety and Posttraumatic Stress Influence Cortical Thinning During Adolescence.Journal of the American Academy of Child and Adolescent Psychiatry · 2021Article
- Cortical thickness distinguishes between major depression and schizophrenia in adolescents.BMC psychiatry · 2021Article
- Longitudinal effects of rTMS on neuroplasticity in chronic treatment-resistant depression.European archives of psychiatry and clinical neuroscience · 2021Article
- Depression, fitness, and student willingness to pursue university counseling and alternative antidepressant options.Journal of education and health promotion · 2021Article
- A neural mechanism for affective well-being: Subgenual cingulate cortex mediates real-life effects of nonexercise activity on energy.Science advances · 2020Article
- Resilience and cortical thickness: a MRI study.European archives of psychiatry and clinical neuroscience · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundFew studies have investigated the relationship between structural brain abnormalities and dimensions of depressive symptomatology.
methodsIn the current study, we examined the relationship between cortical structural abnormalities and specific behavioral dimensions relevant to depression in a sample of unmedicated patients with major depressive disorder (MDD, n=57) and demographically similar healthy control volunteers (HC, n=29). All subjects underwent diagnostic assessment with the SCID, MRI at 3T, and dimensional assessments using the visual analog scales (VAS). Cortical regions were extracted for each subject, and group comparisons of cortical volume (CV), surface area (SA), and cortical thickness (CT) were performed controlling for multiple comparisons using a bootstrapping technique. Regions demonstrating group differences were analyzed for correlation with specific dimensions assessments.
resultsAs compared with HC, MDD subjects exhibited reduced CV within the left supramarginal gyrus, right ventrolateral prefrontal cortex (VLPFC), entorhinal cortex, parahippocampal gyrus, fusiform gyrus and pericalcarine; reduced SA in the right VLPFC, cuneus, and left temporal pole; and reduced CT in the right rostral anterior cingulate cortex (rACC) (all p's<0.05, corrected). The largest effect occurred within the right VLPFC for CV and SA (MDD<HC; effect sizes: 0.60). CV in the right VLPFC inversely correlated with sadness, fatigue and worry; CT in the right rACC inversely correlated with irritability and fatigue. LIMITATIONS: Future studies will be required to further map the anatomical changes in depression to behavioral dimensions.
conclusionsOur results indicate that specific cortical abnormalities are associated with specific behavioral components linked to depression.
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