Evidence map›Paper›PMID 26569585›Full record

ArticleThe Journal of investigative dermatology2015

Beyond Red Hair and Sunburns: Uncovering the Molecular Mechanisms of MC1R Signaling and Repair of UV-Induced DNA Damage.

Pamela B Cassidy, Zalfa A Abdel-Malek, Sancy A Leachman

Open access · bronzeAbstract readComment
In one paragraph

Article in The Journal of investigative dermatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Cutaneous melanoma.Nature reviews. Disease primers · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Pamela B CassidyDepartment of Dermatology, Oregon Health & Science University, Portland, Oregon, USA.
Zalfa A Abdel-MalekDepartment of Dermatology, University of Cincinnati, Cincinnati, Ohio, USA.
Sancy A LeachmanDepartment of Dermatology, Oregon Health & Science University, Portland, Oregon, USA. Electronic address: leachmas@ohsu.edu.
Oregon Health & Science University · USUniversity of Cincinnati · US

Funding

Personalized melanoma chemopreventionR01CA166710 · NCI · UNIVERSITY OF UTAH · PI CASSIDY, PAMELA B., GROSSMAN, DOUGLAS · 2012 to 2016
$1.6M
How p16 and MC1R mutations synergistically exacerbate melanoma risk.R21CA183440 · NCI · UNIVERSITY OF CINCINNATI · PI ABDEL-MALEK, ZALFA, CASSIDY, PAMELA B. · 2014 to 2015
$389k
NCI NIH HHS R01 CA166710NCI NIH HHS R21 CA183440
6 · The paper itself

Abstract

Scientists at the University of Kentucky are unraveling the details of DNA-damage repair in the melanocyte, with an eye towards finding druggable targets for melanoma prevention. Jarret et al., (2015, this issue) report in this issue three new assays that can yield mechanistic information about nucleotide excision repair (NER) stimulated by cAMP-dependent signaling downstream of the melanocortin-1 receptor (MC1R).

Indexed as

DNA RepairHumansMelanocytesReceptor, Melanocortin, Type 1Receptor, Melanocortin, Type 1

Identifiers

PMID26569585
PMCPMC4648680
OpenAlexW2277707276

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.