ArticlePloS one2015
NopC Is a Rhizobium-Specific Type 3 Secretion System Effector Secreted by Sinorhizobium (Ensifer) fredii HH103.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- Soybean GTPase RAC1 interacts with the rhizobial effector NopC to promote root nodulation and improve yield.Plant communications · 2026Article
- Calcium Induces the Cleavage of NopA and Regulates the Expression of Nodulation Genes and Secretion of T3SS Effectors inInternational journal of molecular sciences · 2024Article
- NopAA and NopD Signaling Association-Related GeneInternational journal of molecular sciences · 2023Article
- Signaling in Legume-Rhizobia Symbiosis.International journal of molecular sciences · 2023Review
- Multitask Approach to Localize Rhizobial Type Three Secretion System Effector Proteins Inside Eukaryotic Cells.Plants (Basel, Switzerland) · 2023Article
- Non-Ionic Osmotic Stress Induces the Biosynthesis of Nodulation Factors and Affects Other Symbiotic Traits inBiology · 2023Article
- Effector-Dependent and -Independent Molecular Mechanisms of Soybean-Microbe Interaction.International journal of molecular sciences · 2022Review
- The Bradyrhizobium Sp. LmicA16 Type VI Secretion System Is Required for Efficient Nodulation of Lupinus Spp.Microbial ecology · 2022Article
- The Rhizobial Type 3 Secretion System: The Dr. Jekyll and Mr. Hyde in the Rhizobium-Legume Symbiosis.International journal of molecular sciences · 2022Review
- Surface Motility Regulation ofInternational journal of molecular sciences · 2022Article
- Article
- Varietas Delectat: Exploring Natural Variations in Nitrogen-Fixing Symbiosis Research.Frontiers in plant science · 2022Review
- Genetic Diversity of Type 3 Secretion System inFrontiers in microbiology · 2021Article
- Phylogenetic distribution and evolutionary dynamics ofMicrobial genomics · 2020Article
- Identification ofGenes · 2020Article
- The Role of Secretion Systems, Effectors, and Secondary Metabolites of Beneficial Rhizobacteria in Interactions With Plants and Microbes.Frontiers in plant science · 2020Review
- QTL Mapping and Data Mining to Identify Genes Associated With theFrontiers in plant science · 2020Article
- The genome of Ensifer alkalisoli YIC4027 provides insights for host specificity and environmental adaptations.BMC genomics · 2019Article
- High-Throughput Mass Spectrometric Analysis of the Whole Proteome and Secretome FromFrontiers in microbiology · 2019Article
- Identification of Soybean Genes Whose Expression is Affected by theInternational journal of molecular sciences · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sinorhizobium (Ensifer) fredii HH103 is a broad host-range nitrogen-fixing bacterium able to nodulate many legumes, including soybean. In several rhizobia, root nodulation is influenced by proteins secreted through the type 3 secretion system (T3SS). This specialized secretion apparatus is a common virulence mechanism of many plant and animal pathogenic bacteria that delivers proteins, called effectors, directly into the eukaryotic host cells where they interfere with signal transduction pathways and promote infection by suppressing host defenses. In rhizobia, secreted proteins, called nodulation outer proteins (Nops), are involved in host-range determination and symbiotic efficiency. S. fredii HH103 secretes at least eight Nops through the T3SS. Interestingly, there are Rhizobium-specific Nops, such as NopC, which do not have homologues in pathogenic bacteria. In this work we studied the S. fredii HH103 nopC gene and confirmed that its expression was regulated in a flavonoid-, NodD1- and TtsI-dependent manner. Besides, in vivo bioluminescent studies indicated that the S. fredii HH103 T3SS was expressed in young soybean nodules and adenylate cyclase assays confirmed that NopC was delivered directly into soybean root cells by means of the T3SS machinery. Finally, nodulation assays showed that NopC exerted a positive effect on symbiosis with Glycine max cv. Williams 82 and Vigna unguiculata. All these results indicate that NopC can be considered a Rhizobium-specific effector secreted by S. fredii HH103.
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