ReviewAnnals of the American Thoracic Society2016
Treatment of Obstructive Sleep Apnea. Prospects for Personalized Combined Modality Therapy.
Review in Annals of the American Thoracic Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02714400 (The Impact of Venlafaxine on Apnea Hypopnea Index in Patients With Obstructive Sleep Apnea), which is not on this map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Impact of Venlafaxine on Apnea Hypopnea Index in Patients With Obstructive Sleep Apnea
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- European Respiratory Society guideline on non-CPAP therapies for obstructive sleep apnoea.European respiratory review : an official journal of the European Respiratory Society · 2021Guideline
- Electrical stimulation as a therapeutic approach in obstructive sleep apnea - a meta-analysis.Sleep & breathing = Schlaf & Atmung · 2021Pooled it
- Effectiveness of inspiratory muscle training on sleep and functional capacity to exercise in obstructive sleep apnea: a randomized controlled trial.Sleep & breathing = Schlaf & Atmung · 2018Trial
- Trial
- Chinese Guidelines for the Diagnosis and Surgical Treatment of Adult Obstructive Sleep Apnea (2024).World journal of otorhinolaryngology - head and neck surgery · 2026Article
- Acute Heart Failure and Central Sleep Apnea.Sleep medicine clinics · 2025Review
- Factors associated with treatment adherence to mandibular advancement devices: a scoping review.Sleep & breathing = Schlaf & Atmung · 2023Article
- Positive Airway Pressure Adherence and Health Care Resource Utilization in Patients With Obstructive Sleep Apnea and Heart Failure With Reduced Ejection Fraction.Journal of the American Heart Association · 2023Article
- Impact of Unintentional Air Leaks on Automatic Positive Airway Pressure Device Performance in Simulated Sleep Apnea Events.Respiratory care · 2023Article
- Patient-Centered Therapy for Obstructive Sleep Apnea: A Review.Medicina (Kaunas, Lithuania) · 2022Review
- Reversible Verbal Memory Integration Deficits in Obstructive Sleep Apnoea.Psychologica Belgica · 2021Article
- Positive Airway Pressure Therapy Adherence with Mask Resupply: A Propensity-Matched Analysis.Journal of clinical medicine · 2021Article
- Breathing Re-Education and Phenotypes of Sleep Apnea: A Review.Journal of clinical medicine · 2021Review
- Lacune is the stroke subtype linked to obstructive sleep apnea.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Article
- Obstructive Sleep Apnea, Hypertension, and Cardiovascular Risk: Epidemiology, Pathophysiology, and Management.Current cardiology reports · 2020Review
- Positional Sleep Apnea Among Regional and Remote Australian Population and Simulated Positional Treatment Effects.Nature and science of sleep · 2020Article
- The Effect of the Modified Jaw-Thrust Maneuver on the Depth of Sedation During Drug-Induced Sleep Endoscopy.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019Article
- Drug-Induced Sleep Endoscopy: Clinical Application and Surgical Outcomes.Healthcare (Basel, Switzerland) · 2019Review
- Prediction of Obstructive Sleep Apnea Based on Respiratory Sounds Recorded Between Sleep Onset and Sleep Offset.Clinical and experimental otorhinolaryngology · 2019Article
- Relationship Between Sleep Apnea and Coronary Artery Calcium in Patients With Ischemic Stroke.Frontiers in neurology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Obstructive sleep apnea (OSA) is a common sleep disorder with serious associated morbidities. Although several treatment options are currently available, variable efficacy and adherence result in many patients either not being treated or receiving inadequate treatment long term. Personalized treatment based on relevant patient characteristics may improve adherence to treatment and long-term clinical outcomes. Four key traits of upper airway anatomy and neuromuscular control interact to varying degrees within individuals to cause OSA. These are: (1) the pharyngeal critical closing pressure, (2) the stability of ventilator chemoreflex feedback control (loop gain), (3) the negative intraesophageal pressure that triggers arousal (arousal threshold), and (4) the level of stimulus required to activated upper airway dilator muscles (upper airway recruitment threshold). Simplified diagnostic methods are being developed to assess these pathophysiological traits, potentially allowing prediction of which treatment would best suit each patient. In contrast to current practice of using various treatment modes alone, model predictions and pilot clinical trials show improved outcomes by combining several treatments targeted to each patient's pathophysiology profile. These developments could theoretically improve efficacy and adherence to treatment and in turn reduce the social and economic health burden of OSA and the associated life-threatening morbidities. This article reviews OSA pathophysiology and identifies currently available and investigational treatments that may be combined in the future to optimize therapy based on individual profiles of key patient pathophysiological traits.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.