Evidence map›Paper›PMID 26569298›Full record

SynthesisNutrients2015

Association of Dietary Vitamin A and β-Carotene Intake with the Risk of Lung Cancer: A Meta-Analysis of 19 Publications.

Na Yu, Xinming Su, Zanfeng Wang, Bing Dai, Jian Kang

Open access · goldAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nutrients, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 6 pooled it
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 6 syntheses or guidelines pooled it, 75 citations in OpenAlex.

  1. Pooled it
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  7. Review
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  10. Article
  11. Fat-soluble Vitamins and Lung Cancer: Where We Are?Recent patents on anti-cancer drug discovery · 2025
    Review
  12. Review
  13. Article
  14. Review
  15. [Research Progress of the Effect of Mediterranean Diet on the Correlation of Lung Cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Na YuDepartment of Respiratory Medicine, The First Hospital of China Medical University, No.155 Nanjing North Street, He-ping District, Shenyang 110001, Liaoning, China. nayu888@yeah.net.
Xinming SuDepartment of Respiratory Medicine, The First Hospital of China Medical University, No.155 Nanjing North Street, He-ping District, Shenyang 110001, Liaoning, China. xinmingsu123@yeah.net.
Zanfeng WangDepartment of Respiratory Medicine, The First Hospital of China Medical University, No.155 Nanjing North Street, He-ping District, Shenyang 110001, Liaoning, China. zanfengwang123@yeah.net.
Bing DaiDepartment of Respiratory Medicine, The First Hospital of China Medical University, No.155 Nanjing North Street, He-ping District, Shenyang 110001, Liaoning, China. bingdai123@yeah.net.
Jian KangDepartment of Respiratory Medicine, The First Hospital of China Medical University, No.155 Nanjing North Street, He-ping District, Shenyang 110001, Liaoning, China. kangjian58@163.com.
First Hospital of China Medical University · CNChina Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Whether dietary β-carotene and vitamin A intake protect against lung cancer risk is not clear. Therefore, we performed this meta-analysis to investigate the association between them. The related articles were searched using the databases PubMed and the Web of Knowledge up to May 2015. We used the random-effect model to estimate the relative risk (RR) and their 95% CI. Small-study effect was assessed using Egger's test. In total, 19 studies comprising 10,261 lung cancer cases met the inclusion criteria. The pooled RR and their 95% CI was 0.855 (0.739-0.989) for higher category of dietary vitamin A intake and lung cancer risk, especially among Asian populations and in the cohort studies. Evidence from 18 studies suggested that higher category of dietary β-carotene intake could reduce lung cancer risk (0.768 (0.675-0.874)).The associations were also significant in American and Asian populations. In conclusions, higher category of dietary β-carotene and vitamin A intakes could reduce the risk of lung cancer. However, the dose-response analysis was not performed due to the limited data in each individual study. Due to this limitation, further studies with detailed dose, cases and person-years for β-carotene and vitamin A of each category are wanted to assess this dose-response association.

Indexed as

DietAnimalsbeta CaroteneDatabases, FactualDisease Models, AnimalHumansLung NeoplasmsRisk FactorsSensitivity and SpecificityVitamin Abeta CaroteneVitamin Alung cancermeta-analysisvitamin Aβ-carotene

Identifiers

PMID26569298
PMCPMC4663591
OpenAlexW2163461405

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.