Observational studyNutrients2015
Inverse Correlation between Vitamin D and C-Reactive Protein in Newborns.
Observational study in Nutrients, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Low-grade inflammation from prenatal period to age 6-8 years in a Vitamin D trial.Pediatric research · 2024Trial
- Subclinical inflammation in children with Down syndrome: implications for preventive care.Annals of pediatric endocrinology & metabolism · 2026Article
- Vitamin D, C-Reactive Protein, and Increased Fall Risk: A Genetic Epidemiological Study.Nutrients · 2024Observational
- Associations of serum 25-hydroxyvitamin D with hsCRP and other novel inflammatory biomarkers in children: a cross-sectional study.BMJ open · 2024Article
- Association of low vitamin D level and full-term early-onset neonatal sepsis; a case-control study.Italian journal of pediatrics · 2024Article
- C-reactive protein as a novel biomarker for vitamin D deficiency in alopecia areata.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Article
- HAART induced inflammation, toxicity and its determinants among HIV positive children in Addis Ababa, Ethiopia.Heliyon · 2023Article
- Maternal vitamin D status and risk of childhood overweight at 5 years of age in two Nordic cohort studies.Frontiers in nutrition · 2023Article
- Maternal vitamin D status in relation to infant BMI growth trajectories up to 2 years of age in two prospective pregnancy cohorts.Obesity science & practice · 2022Article
- The effect of vitamin D3 and thyroid hormones on the capillaroscopy-confirmed microangiopathy in pediatric patients with a suspicion of systemic connective tissue disease-a single-center experience with Raynaud phenomenon.Rheumatology international · 2021Observational
- Vitamin D Attenuates Ischemia/Reperfusion-Induced Cardiac Injury by Reducing Mitochondrial Fission and Mitophagy.Frontiers in pharmacology · 2020Article
- Vitamin D status affects the relationship between lipid profile and high-sensitivity C-reactive protein.Nutrition & metabolism · 2020Article
- The Preoperative Supplementation With Vitamin D Attenuated Pain Intensity and Reduced the Level of Pro-inflammatory Markers in Patients After Posterior Lumbar Interbody Fusion.Frontiers in pharmacology · 2019Article
- Higher maternal vitamin D concentrations are associated with longer leukocyte telomeres in newborns.Maternal & child nutrition · 2018Article
- They Are What You Eat: Can Nutritional Factors during Gestation and Early Infancy Modulate the Neonatal Immune Response?Frontiers in immunology · 2017Review
- Anti-Inflammatory Effects of Vitamin D on Human Immune Cells in the Context of Bacterial Infection.Nutrients · 2016Article
- Maternal vitamin D depletion alters DNA methylation at imprinted loci in multiple generations.Clinical epigenetics · 2016Article
- Is Vitamin D Deficiency Implicated in Autonomic Dysfunction?Journal of pediatric neurosciencesReview
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Some studies suggested that adequate vitamin D might reduce inflammation in adults. However, little is known about this association in early life. We aimed to determine the relationship between cord blood 25-hydroxyvitamin D (25(OH)D) and C-reactive protein (CRP) in neonates. Cord blood levels of 25(OH)D and CRP were measured in 1491 neonates in Hefei, China. Potential confounders including maternal sociodemographic characteristics, perinatal health status, lifestyle, and birth outcomes were prospectively collected. The average values of cord blood 25(OH)D and CRP were 39.43 nmol/L (SD = 20.35) and 6.71 mg/L (SD = 3.07), respectively. Stratified by 25(OH)D levels, per 10 nmol/L increase in 25(OH)D, CRP decreased by 1.42 mg/L (95% CI: 0.90, 1.95) among neonates with 25(OH)D <25.0 nmol/L, and decreased by 0.49 mg/L (95% CI: 0.17, 0.80) among neonates with 25(OH)D between 25.0 nmol/L and 49.9 nmol/L, after adjusting for potential confounders. However, no significant association between 25(OH)D and CRP was observed among neonates with 25(OH)D ≥50 nmol/L. Cord blood 25(OH)D and CRP levels showed a significant seasonal trend with lower 25(OH)D and higher CRP during winter-spring than summer-autumn. Stratified by season, a significant linear association of 25(OH)D with CRP was observed in neonates born in winter-spring (adjusted β = -0.11, 95% CI: -0.13, -0.10), but not summer-autumn. Among neonates born in winter-spring, neonates with 25(OH)D <25 nmol/L had higher risk of CRP ≥10 mg/L (adjusted OR = 3.06, 95% CI: 2.00, 4.69), compared to neonates with 25(OH)D ≥25 nmol/L. Neonates with vitamin D deficiency had higher risk of exposure to elevated inflammation at birth.
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