ArticleMolecules (Basel, Switzerland)2015
Auraptene Acts as an Anti-Inflammatory Agent in the Mouse Brain.
Article in Molecules (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04744922 (Clinical and Biological Effects of Citrus-phytochemicals in Subjective Cognitive Decline), which is not on this map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical and Biological Effects of Citrus-phytochemicals in Subjective Cognitive Decline: a Pilot Randomized Controlled Trial.
Who cites it
16 citing papers in PubMed, 47 citations in OpenAlex.
- Cognitive and biological effects of citrus phytochemicals in subjective cognitive decline: a 36-week, randomized, placebo-controlled trial.Nutrition journal · 2022Trial
- Auraptene in the Peels of Citrus Kawachiensis (Kawachibankan) Contributes to the Preservation of Cognitive Function: A Randomized, Placebo-Controlled, Double-Blind Study in Healthy Volunteers.The journal of prevention of Alzheimer's disease · 2018Trial
- Loss of microglial Arid1a exacerbates microglial scar formation via elevated CCL5 after traumatic brain injury.Cell communication and signaling : CCS · 2024Article
- Antibacterial Activity for Synthesized Coumarin Derivatives and a Coumarin Component of Lime Peel (Bioengineering (Basel, Switzerland) · 2024Article
- Auraptene, a Monoterpene Coumarin, Inhibits LTA-Induced Inflammatory Mediators via Modulating NF-Evidence-based complementary and alternative medicine : eCAM · 2021Article
- From Preclinical Stroke Models to Humans: Polyphenols in the Prevention and Treatment of Stroke.Nutrients · 2020Review
- Citrus Auraptene Induces Expression of Brain-Derived Neurotrophic Factor in Neuro2a Cells.Molecules (Basel, Switzerland) · 2020Article
- Potency of Selected Berries, Grapes, and Citrus Fruit as Neuroprotective Agents.Evidence-based complementary and alternative medicine : eCAM · 2020Review
- Citrus Auraptene Induces Glial Cell Line-Derived Neurotrophic Factor in C6 Cells.International journal of molecular sciences · 2019Article
- Auraptene Mitigates Parkinson's Disease-Like Behavior by Protecting Inhibition of Mitochondrial Respiration and Scavenging Reactive Oxygen Species.International journal of molecular sciences · 2019Article
- The Protective Effect of Auraptene Against Oxidative Stress and Pentylenetetrazol-Induced Chemical Kindling in Mice.Iranian journal of pharmaceutical research : IJPR · 2019Article
- Inhibitory Effects of Auraptene and Naringin on Astroglial Activation, Tau Hyperphosphorylation, and Suppression of Neurogenesis in the Hippocampus of Streptozotocin-Induced Hyperglycemic Mice.Antioxidants (Basel, Switzerland) · 2018Article
- Inhibitory effects of Ponciri Fructus on testosterone-induced benign prostatic hyperplasia in rats.BMC complementary and alternative medicine · 2017Article
- Permeation of Polymethoxyflavones into the Mouse Brain and Their Effect on MK-801-Induced Locomotive Hyperactivity.International journal of molecular sciences · 2017Article
- Auraptene and Other Prenyloxyphenylpropanoids Suppress Microglial Activation and Dopaminergic Neuronal Cell Death in a Lipopolysaccharide-Induced Model of Parkinson's Disease.International journal of molecular sciences · 2016Article
- Coumarins, Xanthones and Related Compounds.Molecules (Basel, Switzerland) · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The anti-inflammatory activity of auraptene (AUR), a citrus coumarin, in peripheral tissues is well-known, and we previously demonstrated that AUR exerts anti-inflammatory effects in the ischemic brain; the treatment of mice with AUR for eight days immediately after ischemic surgery suppressed demise and neuronal cell death in the hippocampus, possibly through its anti-inflammatory effects in the brain. We suggested that these effects were at least partly mediated by the suppression of inflammatory mediators derived from astrocytes. The present study showed that (1) AUR, as a pretreatment for five days before and another three days after ischemic surgery, suppressed microglial activation, cyclooxygenase (COX)-2 expression in astrocytes, and COX-2 mRNA expression in the hippocampus; (2) AUR suppressed the lipopolysaccharide-induced expression of COX-2 mRNA and the mRNA of pro-inflammatory cytokines in cultured astrocytes; (3) AUR was still detectable in the brain 60 min after its intraperitoneal administration. These results support our previous suggestion that AUR directly exerts anti-inflammatory effects on the brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.