ReviewChannels (Austin, Tex.)2015
Role of volume-regulated and calcium-activated anion channels in cell volume homeostasis, cancer and drug resistance.
Review in Channels (Austin, Tex.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 50 citations in OpenAlex.
- Piezo1 is an essential player in volume regulation of human glioblastoma cells.The Journal of physiology · 2025Article
- Piezo1, the new actor in cell volume regulation.Pflugers Archiv : European journal of physiology · 2024Review
- Apoptotic volume decrease (AVD) in AFrontiers in physiology · 2023Article
- Deficiency of TTYH1 Expression Reduces the Migration and Invasion of U2OS Human Osteosarcoma Cells.Life (Basel, Switzerland) · 2022Article
- The Important Role of Ion Transport System in Cervical Cancer.International journal of molecular sciences · 2021Review
- The Role of Chloride Channels in the Multidrug Resistance.Membranes · 2021Review
- Review
- Glial Chloride Channels in the Function of the Nervous System Across Species.Advances in experimental medicine and biology · 2021Article
- Cation-Chloride Cotransporters, Na/K Pump, and Channels in Cell Water and Ion Regulation:Frontiers in cell and developmental biology · 2021Article
- Flow fluorometry quantification of anion channel VRAC subunit LRRC8A at the membrane of living U937 cells.Channels (Austin, Tex.) · 2020Article
- Drug development in targeting ion channels for brain edema.Acta pharmacologica Sinica · 2020Article
- A Reverse-Osmosis Model of Apoptotic Shrinkage.Frontiers in cell and developmental biology · 2020Article
- Balance of NaFrontiers in cell and developmental biology · 2020Article
- The multifaceted role of TMEM16A in cancer.Cell calcium · 2019Review
- Acid- and Volume-Sensitive Chloride Currents in Microglial Cells.International journal of molecular sciences · 2019Article
- Review
- Article
- A Tool for Computation of Changes in NaFrontiers in cell and developmental biology · 2019Article
- Cryo-EM structures of the human volume-regulated anion channel LRRC8.Nature structural & molecular biology · 2018Article
- Facilitating the Cellular Accumulation of Pt-Based Chemotherapeutic Drugs.International journal of molecular sciences · 2018Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Volume-regulated channels for anions (VRAC) / organic osmolytes (VSOAC) play essential roles in cell volume regulation and other cellular functions, e.g. proliferation, cell migration and apoptosis. LRRC8A, which belongs to the leucine rich-repeat containing protein family, was recently shown to be an essential component of both VRAC and VSOAC. Reduced VRAC and VSOAC activities are seen in drug resistant cancer cells. ANO1 is a calcium-activated chloride channel expressed on the plasma membrane of e.g., secretory epithelia. ANO1 is amplified and highly expressed in a large number of carcinomas. The gene, encoding for ANO1, maps to a region on chromosome 11 (11q13) that is frequently amplified in cancer cells. Knockdown of ANO1 impairs cell proliferation and cell migration in several cancer cells. Below we summarize the basic biophysical properties of VRAC, VSOAC and ANO1 and their most important cellular functions as well as their role in cancer and drug resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.