Evidence map›Paper›PMID 26568914›Full record

ReviewWorld journal of virology2015

Hepatitis delta virus: A fascinating and neglected pathogen.

Celso Cunha, João Paulo Tavanez, Severin Gudima

Open access · diamondAbstract readReview
In one paragraph

Review in World journal of virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Mode and tempo of human hepatitis virus evolution.Computational and structural biotechnology journal · 2019
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Celso CunhaCelso Cunha, João Paulo Tavanez, Global Health and Tropical Medicine, Medical Microbiology Unit, Institute of Hygiene and Tropical Medicine, Universidade Nova de Lisboa, 1349-008 Lisboa, Portugal.
João Paulo TavanezCelso Cunha, João Paulo Tavanez, Global Health and Tropical Medicine, Medical Microbiology Unit, Institute of Hygiene and Tropical Medicine, Universidade Nova de Lisboa, 1349-008 Lisboa, Portugal.
Severin GudimaCelso Cunha, João Paulo Tavanez, Global Health and Tropical Medicine, Medical Microbiology Unit, Institute of Hygiene and Tropical Medicine, Universidade Nova de Lisboa, 1349-008 Lisboa, Portugal.
Universidade Nova de Lisboa · PTUniversity of Kansas Medical Center · US

Funding

Super-infection and virus spread during chronic hepadnaviral infectionR01CA166213 · NCI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI GUDIMA, SEVERIN O, MENNE, STEPHAN · 2012 to 2016
$1.6M
Persistence of hepatitis delta virus infection in absence of HBV replicationR21AI099696 · NIAID · UNIVERSITY OF KANSAS MEDICAL CENTER · PI GUDIMA, SEVERIN O · 2013 to 2014
$412k
HDV spread during chronic infection as a novel target for antiviral interventionR21AI097647 · NIAID · UNIVERSITY OF KANSAS MEDICAL CENTER · PI GUDIMA, SEVERIN O · 2012 to 2013
$402k
NCI NIH HHS R01 CA166213NIAID NIH HHS R21 AI097647NIAID NIH HHS R21 AI099696
6 · The paper itself

Abstract

Hepatitis delta virus (HDV) is the etiologic agent of the most severe form of virus hepatitis in humans. Sharing some structural and functional properties with plant viroids, the HDV RNA contains a single open reading frame coding for the only virus protein, the Delta antigen. A number of unique features, including ribozyme activity, RNA editing, rolling-circle RNA replication, and redirection for a RNA template of host DNA-dependent RNA polymerase II, make this small pathogen an excellent model to study virus-cell interactions and RNA biology. Treatment options for chronic hepatitis Delta are scarce and ineffective. The disease burden is perhaps largely underestimated making the search for new, specific drugs, targets, and treatment strategies an important public health challenge. In this review we address the main features of virus structure, replication, and interaction with the host. Virus pathogenicity and current treatment options are discussed in the light of recent developments.

Indexed as

Hepatitis B virusHepatitis delta virusPathogenesisRNA replicationTreatment

Identifiers

PMID26568914
PMCPMC4641224
OpenAlexW2410450410

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.