ArticleIranian Red Crescent medical journal2015
Status of p53 and p27(KIP1) in Iranian Patients With Oral Squamous Cell Carcinoma.
Article in Iranian Red Crescent medical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Current and Emerging Protein Biomarkers for the Diagnosis and Prognosis of Head and Neck Cancer.Genes · 2025Review
- Current and Emerging Diagnostic, Prognostic, and Predictive Biomarkers in Head and Neck Cancer.Biomedicines · 2024Review
- Immunoexpression of p53 mutant-type in Iranian patients with primary and recurrence oral squamous cell carcinoma.European journal of translational myology · 2022Article
- Immunohistochemical over expression of p53 in head and neck Squamous cell carcinoma: clinical and prognostic significance.BMC research notes · 2018Article
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4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlterations in p53 and p27(KIP1) have been documented as important events in the carcinogenesis of various cancers, but their prognostic role in oral squamous cell carcinoma (OSCC) remains controversial.
objectivesThe present investigation aimed to evaluate the clinicopathologic and prognostic significance of p53 and p27(KIP1) expression in a group of Iranian patients with OSCC. PATIENTS AND
methodsIn this analytical cross-sectional study, medical records of patients with primary OSCC, diagnosed from 1994 to 2004 were reviewed and 28 subjects were selected based on the inclusion/exclusion criteria. Immunohistochemical staining using monoclonal antibodies against p53 and p27(KIP1) was performed on representative archival paraffin blocks. Demographic data along with information on p53 and p27(KIP1) expression, recurrence, and tumor grade was statistically analyzed using the Fischer exact test. Prognostic factors for overall survival were determined by Cox regression analysis (P < 0.05).
resultsp53 and p27(KIP1) expression were found in 28.57% (8 positive versus 20 negative) and 67.85% (19 positive versus 9 negative) of OSCC cases, respectively. There was no significant association between these two proteins (P = 0.371), and neither of them showed a significant relationship with the studied clinicopathologic variables (P > 0.05). In survival analysis, only histopathologic differentiation (17 low and moderate, 11 poor) demonstrated a significant correlation with overall survival (P = 0.048).
conclusionsDespite the fact that abnormalities in p53 and p27(KIP1) may be involved in the development of OSCC, their clinical significance in the studied population seems limited. Further investigation on the combined p53/p27(KIP1) expression may be helpful in predicting the biologic behavior of this tumor.
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