Evidence map›Paper›PMID 26568842›Full record

ArticleCell death discovery2015

Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemia.

Alexander S Watson, Thomas Riffelmacher, Amanda Stranks, Owen Williams, Jasper De Boer, Kelvin Cain, Marion MacFarlane, Joanna McGouran, Benedikt Kessler, Shivani Khandwala and 9 more

Open access · goldAbstract read
In one paragraph

Article in Cell death discovery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 1 pooled it
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 1 synthesis or guideline pooled it, 161 citations in OpenAlex.

  1. Pooled it
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  7. Article
  8. A novel regulatory circuit of ATG4B and SESN3 promotes T cell leukemogenesis.Journal of experimental & clinical cancer research : CR · 2025
    Article
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  12. Article
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  20. Autophagy and Its Lineage-Specific Roles in the Hematopoietic System.Oxidative medicine and cellular longevity · 2023
    Review

36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 1 country.

Alexander S WatsonTranslational Immunology Lab, BRC- NIHR, John Radcliffe Hospital, Experimental Medicine, Nuffield Department of Medicine, Oxford OX3 9DU, UK ; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK.
Thomas RiffelmacherMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK.
Amanda StranksMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK.
Owen WilliamsMolecular Haematology and Cancer Biology Unit, UCL Institute of Child Health, University College London, London WC1N 1EH, UK.
Jasper De BoerMolecular Haematology and Cancer Biology Unit, UCL Institute of Child Health, University College London, London WC1N 1EH, UK.
Kelvin CainMRC Toxicology Unit, Hodgkin Building, University of Leicester, PO Box 138, Lancaster Road, Leicester LE1 9HN, UK.
Marion MacFarlaneMRC Toxicology Unit, Hodgkin Building, University of Leicester, PO Box 138, Lancaster Road, Leicester LE1 9HN, UK.
Joanna McGouranTarget Discovery Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK.
Benedikt KesslerTarget Discovery Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK.
Shivani KhandwalaMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK.
Onima ChowdhuryHaematopoietic Stem Cell Biology, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK.
Daniel PulestonMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK.
Kanchan PhadwalTranslational Immunology Lab, BRC- NIHR, John Radcliffe Hospital, Experimental Medicine, Nuffield Department of Medicine, Oxford OX3 9DU, UK.
Monika MortensenMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK.
David FergusonNuffield Department of Clinical and Laboratory Sciences, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Elizabeth SoilleuxNuffield Department of Clinical and Laboratory Sciences, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Petter WollHaematopoietic Stem Cell Biology, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK.
Sten Eirik W JacobsenHaematopoietic Stem Cell Biology, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK.
Anna Katharina SimonTranslational Immunology Lab, BRC- NIHR, John Radcliffe Hospital, Experimental Medicine, Nuffield Department of Medicine, Oxford OX3 9DU, UK ; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK.
John Radcliffe Hospital · GBMRC Human Immunology Unit · GBUniversity College London · GBUniversity of Leicester · GBUniversity of Oxford · GB

Funding

Biotechnology and Biological Sciences Research Council BB/G021422/1Medical Research Council G0501838Medical Research Council MC_U132685863Medical Research Council MC_UU_12009/5Wellcome Trust 103830
6 · The paper itself

Abstract

Decreased autophagy contributes to malignancies, however it is unclear how autophagy impacts on tumour growth. Acute myeloid leukemia (AML) is an ideal model to address this as (i) patient samples are easily accessible, (ii) the hematopoietic stem and progenitor population (HSPC) where transformation occurs is well characterized, and (iii) loss of the key autophagy gene

Indexed as

Acute Myeloid Leukemia (AML)AutophagyCancerGlycolysisHematopoiesisHematopoietic Stem CellMetabolismMyeloid cells

Identifiers

PMID26568842
PMCPMC4641322
OpenAlexW2201007235

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.