ArticleFuture virology
Norovirus vaccines and potential antinorovirus drugs: recent advances and future perspectives.
Article in Future virology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Impact of Pre-exposure History and Host Genetics on Antibody Avidity Following Norovirus Vaccination.The Journal of infectious diseases · 2017Trial
- Review
- Article
- Putative structural rearrangements associated with the interaction of macrocyclic inhibitors with norovirus 3CL protease.Proteins · 2019Article
- Norovirus antivirals: Where are we now?Medicinal research reviews · 2019Review
- Predicting Directions of Changes in Genotype Proportions Between Norovirus Seasons in Japan.Frontiers in microbiology · 2019Article
- Structure-guided design, synthesis and evaluation of oxazolidinone-based inhibitors of norovirus 3CL protease.European journal of medicinal chemistry · 2018Article
- A model for rapid, active surveillance for medically-attended acute gastroenteritis within an integrated health care delivery system.PloS one · 2018Article
- Therapeutics and Immunoprophylaxis Against Noroviruses and Rotaviruses: The Past, Present, and Future.Current drug metabolism · 2018Review
- Design, synthesis, and evaluation of a novel series of macrocyclic inhibitors of norovirus 3CL protease.European journal of medicinal chemistry · 2017Article
- Structure-based exploration and exploitation of the SEuropean journal of medicinal chemistry · 2017Article
- Norovirus drug candidates that inhibit viral capsid attachment to human histo-blood group antigens.Antiviral research · 2016Review
- Approved Antiviral Drugs over the Past 50 Years.Clinical microbiology reviews · 2016Review
- Antiviral targets of human noroviruses.Current opinion in virology · 2016Review
- Increased and prolonged human norovirus infection in RAG2/IL2RG deficient gnotobiotic pigs with severe combined immunodeficiency.Scientific reports · 2016Article
- Enterobacter cloacae inhibits human norovirus infectivity in gnotobiotic pigs.Scientific reports · 2016Article
- High Protective Efficacy of Probiotics and Rice Bran against Human Norovirus Infection and Diarrhea in Gnotobiotic Pigs.Frontiers in microbiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Human noroviruses (HuNoVs) are a leading cause of acute, nonbacterial gastroenteritis worldwide. The lack of a cell culture system and smaller animal model has delayed the development and commercial availability of vaccines and antiviral drugs. Current vaccines rely on recombinant capsid proteins, such as P particles and virus-like particles (VLPs), which have been promising in clinical trials. Anti-HuNoV drug development is another area of extensive research, including currently available antiviral drugs for other viral pathogens. This review will provide an overview of recent advances in vaccine and antiviral development. The implication of recent advances in HuNoV cell culture for improving vaccine and antiviral development is also discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.