ArticleIranian journal of reproductive medicine2015
Evaluation of CD56(dim) and CD56(bright) natural killer cells in peripheral blood of women with IVF failures.
Article in Iranian journal of reproductive medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 11 citations in OpenAlex.
- Association of recurrent implantation failure and recurrent pregnancy loss with peripheral blood natural killer cells and interferon-gamma level.Obstetrics & gynecology science · 2024Article
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Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfertility is an increasing medical and social problem. In vitro fertilization (IVF) has become a common and accessible treatment for a wide variety of indications that have variable outcomes. Natural killer (NK) cells have been identified as relevant immunological factors involved in reproductive success or failure.
objectiveThe aim of this study was to compare the percentage of peripheral blood CD56(+) (CD56(dim) and CD56(bright)) cells and the level of NK cell in patients with IVF failure with those of successful IVF control women. MATERIALS AND
methodsWe assessed the level of CD56(dim) CD16(+) and CD56(bright) CD16(-) cells in 50 women under IVF treatment and compared between successful IVF and IVF failure with the flowcytometry technique.
resultsOf studied women, 68% did not response to IVF therapy and 32% had successful IVF, the level of CD56(dim) CD16(+) cells in women with IVF failure was significantly higher than successful IVF (p<0.0001) but the level of CD56(bright) CD16(-) cells was not significantly different between women with IVF failure and successful IVF (p=0.28).
conclusionThe results of present study demonstrated that the level of NK cells as a risk factor is associated with pregnancy loss in women with IVF failure. However, number of sample in this study is low and further studies with more sample size are needed to be done. We suggest considering treatment option for women undergoing repeated IVF failure with increased percentage of CD56(dim) cells and the level of peripheral blood NK cell.
Indexed as
Identifiers
26568763PMC4637126W2261026440What OpenQuestion holds
Registered trials
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