ArticleMolecular biology and evolution2016
Restriction-Modification Systems as Mobile Genetic Elements in the Evolution of an Intracellular Symbiont.
Article in Molecular biology and evolution, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
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- Genic Selection Within Prokaryotic Pangenomes.Genome biology and evolution · 2021Review
- Genomic Characterization of a Novel Tenericutes Bacterium from Deep-Sea Holothurian Intestine.Microorganisms · 2020Article
- Parallel reductive genome evolution in Desulfovibrio ectosymbionts independently acquired by Trichonympha protists in the termite gut.The ISME journal · 2020Article
- Genome analyses of uncultured TG2/ZB3 bacteria in 'Margulisbacteria' specifically attached to ectosymbiotic spirochetes of protists in the termite gut.The ISME journal · 2019Article
- Review
- Metagenomic binning of a marine sponge microbiome reveals unity in defense but metabolic specialization.The ISME journal · 2017Article
- Genome Analysis of Endomicrobium proavitum Suggests Loss and Gain of Relevant Functions during the Evolution of Intracellular Symbionts.Applied and environmental microbiology · 2017Article
- Discovery and Complete Genome Sequence of a Bacteriophage from an Obligate Intracellular Symbiont of a Cellulolytic Protist in the Termite Gut.Microbes and environments · 2017Article
- The Evolution of Bacterial Genome Architecture.Frontiers in genetics · 2017Review
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- Comparison of Intracellular "Ca. Endomicrobium Trichonymphae" Genomovars Illuminates the Requirement and Decay of Defense Systems against Foreign DNA.Genome biology and evolution · 2016Article
- Experimental Evolution as an Underutilized Tool for Studying Beneficial Animal-Microbe Interactions.Frontiers in microbiology · 2016Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long-term vertical transmission of intracellular bacteria causes massive genomic erosion and results in extremely small genomes, particularly in ancient symbionts. Genome reduction is typically preceded by the accumulation of pseudogenes and proliferation of mobile genetic elements, which are responsible for chromosome rearrangements during the initial stage of endosymbiosis. We compared the genomes of an endosymbiont of termite gut flagellates, "Candidatus Endomicrobium trichonymphae," and its free-living relative Endomicrobium proavitum and discovered many remnants of restriction-modification (R-M) systems that are consistently associated with genome rearrangements in the endosymbiont genome. The rearrangements include apparent insertions, transpositions, and the duplication of a genomic region; there was no evidence of transposon structures or other mobile elements. Our study reveals a so far unrecognized mechanism for genome rearrangements in intracellular symbionts and sheds new light on the general role of R-M systems in genome evolution.
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