ArticleAngewandte Chemie (International ed. in English)2015
A Bioorthogonal Reaction of N-Oxide and Boron Reagents.
Article in Angewandte Chemie (International ed. in English), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 77 citations in OpenAlex.
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- On-Demand Ligate and Release Strategy Based on Photoclick Reaction in Tandem with Pd-Mediated Deallylation.Angewandte Chemie (International ed. in English) · 2025Article
- Mussel-Derived and Bioclickable Peptide Mimic for Enhanced Interfacial Osseointegration via Synergistic Immunomodulation and Vascularized Bone Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
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- A switchable redox annulation of 2-nitroarylethanols affordingChemical science · 2022Article
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- Reductive site-selective atypicalScience advances · 2022Article
- Bio-clickable mussel-inspired peptides improve titanium-based material osseointegration synergistically with immunopolarization-regulation.Bioactive materials · 2022Article
- A Dansyl Amide N-Oxide Fluorogenic Probe Based on a Bioorthogonal Decaging Reaction.ChemistryOpen · 2021Article
- Unleashing the Power of Bond Cleavage Chemistry in Living Systems.ACS central science · 2021Review
- EnamineACS central science · 2021Article
- Nanozymes with bioorthogonal reaction for intelligence nanorobots.Biophysics reports · 2021Article
- Developing bioorthogonal probes to span a spectrum of reactivities.Nature reviews. Chemistry · 2020Article
- 1,2-Azaborine's Distinct Electronic Structure Unlocks Two New Regioisomeric Building Blocks via Resolution Chemistry.Journal of the American Chemical Society · 2019Article
- Aryl Azides as Phosphine-Activated Switches for Small Molecule Function.Scientific reports · 2019Article
- Site-specific incorporation of quadricyclane into a protein and photocleavage of the quadricyclane ligation adduct.Bioorganic & medicinal chemistry · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The development of bioorthogonal reactions has classically focused on bond-forming ligation reactions. In this report, we seek to expand the functional repertoire of such transformations by introducing a new bond-cleaving reaction between N-oxide and boron reagents. The reaction features a large dynamic range of reactivity, showcasing second-order rate constants as high as 2.3×10(3) M(-1) s(-1) using diboron reaction partners. Diboron reagents display minimal cell toxicity at millimolar concentrations, penetrate cell membranes, and effectively reduce N-oxides inside mammalian cells. This new bioorthogonal process based on miniscule components is thus well-suited for activating molecules within cells under chemical control. Furthermore, we demonstrate that the metabolic diversity of nature enables the use of naturally occurring functional groups that display inherent biocompatibility alongside abiotic components for organism-specific applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.