Evidence map›Paper›PMID 26568457›Full record

ArticleOrganic letters2015

Synthesis of [18F]Arenes via the Copper-Mediated [18F]Fluorination of Boronic Acids.

Andrew V Mossine, Allen F Brooks, Katarina J Makaravage, Jason M Miller, Naoko Ichiishi, Melanie S Sanford, Peter J H Scott

Abstract read
In one paragraph

Article in Organic letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
113citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

113 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Recent advances in [Nuclear medicine and biology · 2026
    Review
  3. NonsteroidalJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  4. Article
  5. High-Yield Room-Temperature ArylACS organic & inorganic Au · 2026
    Article
  6. Fully Automated Azeotropic Drying-Free Synthesis of [Molecules (Basel, Switzerland) · 2026
    Article
  7. Chemical science · 2026
    Article
  8. Aryl Sulfamoyl [Journal of medicinal chemistry · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. A simplified, robust protocol for [Scientific reports · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Improved Radiosynthesis of [ACS infectious diseases · 2025
    Article
  18. Review
  19. Article
  20. Article

53 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Andrew V MossineDepartment of Radiology, University of Michigan Medical School , 1301 Catherine Street, Ann Arbor, Michigan 48109, United States.
Allen F BrooksDepartment of Radiology, University of Michigan Medical School , 1301 Catherine Street, Ann Arbor, Michigan 48109, United States.
Katarina J MakaravageDepartment of Chemistry, University of Michigan , 930 North University Avenue, Ann Arbor, Michigan 48109, United States.
Jason M MillerDepartment of Medicinal Chemistry, University of Michigan , 428 Church Street, Ann Arbor, Michigan 48109, United States.
Naoko IchiishiDepartment of Chemistry, University of Michigan , 930 North University Avenue, Ann Arbor, Michigan 48109, United States.
Melanie S SanfordDepartment of Chemistry, University of Michigan , 930 North University Avenue, Ann Arbor, Michigan 48109, United States.
Peter J H ScottDepartment of Radiology, University of Michigan Medical School , 1301 Catherine Street, Ann Arbor, Michigan 48109, United States.

Funding

C-H Bond Functionalization in Organic SynthesisR01GM073836 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SANFORD, MELANIE S. · 2005 to 2019
$4.0M
Training Future Imaging Scientists for BiomedicineT32EB005172 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FOWLKES, JEFFREY B · 2008 to 2012
$1.1M
NIBIB NIH HHS T32 EB005172NIBIB NIH HHS T32-EB005172NIGMS NIH HHS GM073836NIGMS NIH HHS R01 GM073836
6 · The paper itself

Abstract

A copper-mediated radiofluorination of aryl- and vinylboronic acids with K(18)F is described. This method exhibits high functional group tolerance and is effective for the radiofluorination of a range of electron-deficient, -neutral, and -rich aryl-, heteroaryl-, and vinylboronic acids. This method has been applied to the synthesis of [(18)F]FPEB, a PET radiotracer for quantifying metabotropic glutamate 5 receptors.

Indexed as

Boronic AcidsCatalysisCopperFluorine RadioisotopesMolecular StructureNitrilesPositron-Emission TomographyPyridinesRadiopharmaceuticals3-fluoro-5-((pyridin-3-yl)ethynyl)benzonitrileBoronic AcidsCopperFluorine RadioisotopesNitrilesPyridinesRadiopharmaceuticals

Identifiers

PMID26568457
PMCPMC4672358

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.