ArticleGenome biology and evolution2015
Comparative Genomics of the Genus Porphyromonas Identifies Adaptations for Heme Synthesis within the Prevalent Canine Oral Species Porphyromonas cangingivalis.
Article in Genome biology and evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Porphyromonas gingivalis produces a functional HemH ferrochelatase important for its survival in a heme-limited environment.Scientific reports · 2026Article
- Microbiome-host co-oscillation patterns in shaping ruminal ecosystem from birth to puberty in a goat model.Science China. Life sciences · 2026Article
- Compositional Changes and Comparative Analysis of Oral Microbial Community During the Formation of Canine Dental Calculus.Animals : an open access journal from MDPI · 2025Article
- Possible correlation of specific bacteria detected by using a novel screening method and periodontal disease in dogs.The Journal of veterinary medical science · 2025Article
- Genomic diversity inMicrobial genomics · 2025Article
- PostbioticAnimals : an open access journal from MDPI · 2025Article
- HmuY proteins of theFrontiers in cellular and infection microbiology · 2025Article
- Characterization of oral microbiota in 6-8-month-old small breed dogs.BMC veterinary research · 2024Article
- Host-microbe interactions in the nasal cavity of dogs with chronic idiopathic rhinitis.Frontiers in veterinary science · 2024Article
- Longitudinal Analysis of Canine Oral Microbiome Using Whole Genome Sequencing in Aging Companion Dogs.Animals : an open access journal from MDPI · 2023Article
- Phylogenomic analysis of theFrontiers in microbiology · 2023Article
- Contribution of -Omics Technologies in the Study ofInternational journal of molecular sciences · 2022Review
- Assessment of Changes in the Oral Microbiome That Occur in Dogs with Periodontal Disease.Veterinary sciences · 2021Article
- Influence of the dental topical application of a nisin-biogel in the oral microbiome of dogs: a pilot study.PeerJ · 2021Article
- Phylogenetic diversity inJournal of oral microbiology · 2020Article
- Structural properties of a haemophore facilitate targeted elimination of the pathogen Porphyromonas gingivalis.Nature communications · 2018Article
- Comparative Genomics of the First and Complete Genome of "International journal of genomics · 2018Article
- A structure-derived snap-trap mechanism of a multispecific serpin from the dysbiotic human oral microbiome.The Journal of biological chemistry · 2017Article
- Bacterial intra-species gene loss occurs in a largely clocklike manner mostly within a pool of less conserved and constrained genes.Scientific reports · 2016Article
- Porphyromonas gulae Has Virulence and Immunological Characteristics Similar to Those of the Human Periodontal Pathogen Porphyromonas gingivalis.Infection and immunity · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Porphyromonads play an important role in human periodontal disease and recently have been shown to be highly prevalent in canine mouths. Porphyromonas cangingivalis is the most prevalent canine oral bacterial species in both plaque from healthy gingiva and plaque from dogs with early periodontitis. The ability of P. cangingivalis to flourish in the different environmental conditions characterized by these two states suggests a degree of metabolic flexibility. To characterize the genes responsible for this, the genomes of 32 isolates (including 18 newly sequenced and assembled) from 18 Porphyromonad species from dogs, humans, and other mammals were compared. Phylogenetic trees inferred using core genes largely matched previous findings; however, comparative genomic analysis identified several genes and pathways relating to heme synthesis that were present in P. cangingivalis but not in other Porphyromonads. Porphyromonas cangingivalis has a complete protoporphyrin IX synthesis pathway potentially allowing it to synthesize its own heme unlike pathogenic Porphyromonads such as Porphyromonas gingivalis that acquire heme predominantly from blood. Other pathway differences such as the ability to synthesize siroheme and vitamin B12 point to enhanced metabolic flexibility for P. cangingivalis, which may underlie its prevalence in the canine oral cavity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.