ArticleeLife2015
Bystander hyperactivation of preimmune CD8+ T cells in chronic HCV patients.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01534728 (Identification of HCV Specific T Cells Using Tetramer Technology - TETRA Study), which is not on this map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Identification of HCV Specific T Cells Using Tetramer Technology - TETRA Study
Who cites it
33 citing papers in PubMed, 56 citations in OpenAlex.
- Impact of oncogenic viruses on autoimmune diseases and tumorigenesis.Infectious agents and cancer · 2026Review
- Genetic and transcriptional insights reveal hepatitis C virus as a driver of kidney cancer.Infectious agents and cancer · 2025Article
- Review
- Structural basis for hepatitis E virus neutralization by potent human antibodies.Science advances · 2025Article
- Bystander activated CD8Nature communications · 2024Article
- IL-15-induced CD38Clinical & translational immunology · 2024Article
- Homeostatic cytokines reciprocally modulate the emergence of prenatal effector PLZF+CD4+ T cells in humans.JCI insight · 2023Article
- Article
- Longitudinal liver sampling in patients with chronic hepatitis B starting antiviral therapy reveals hepatotoxic CD8+ T cells.The Journal of clinical investigation · 2023Article
- Enhanced TLR3 responsiveness in hepatitis C virus resistant women from the Irish anti-D cohort.Cell reports. Medicine · 2022Article
- Immune mobilising T cell receptors redirect polyclonal CD8Scientific reports · 2022Article
- Early IFNβ secretion determines variable downstream IL-12p70 responses upon TLR4 activation.Cell reports · 2022Article
- Altered Basal Lipid Metabolism Underlies the Functional Impairment of Naive CD8Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- After virus exposure, early bystander naïve CD8 T cell activation relies on NADFrontiers in immunology · 2022Article
- Significance of bystander T cell activation in microbial infection.Nature immunology · 2022Review
- Chronic Hepatitis C Pathogenesis: Immune Response in the Liver Microenvironment and Peripheral Compartment.Frontiers in cellular and infection microbiology · 2021Article
- Chronic viral infections impinge on naive bystander CD8 T cells.Immunity, inflammation and disease · 2020Article
- High Frequency of Shared Clonotypes in Human T Cell Receptor Repertoires.Cell reports · 2020Article
- CXCR3 Identifies Human Naive CD8Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- The activation of bystander CD8Experimental & molecular medicine · 2019Review
Corrections and comments
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Authors and funding
24 authors at 13 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic infection perturbs immune homeostasis. While prior studies have reported dysregulation of effector and memory cells, little is known about the effects on naïve T cell populations. We performed a cross-sectional study of chronic hepatitis C (cHCV) patients using tetramer-associated magnetic enrichment to study antigen-specific inexperienced CD8(+) T cells (i.e., tumor or unrelated virus-specific populations in tumor-free and sero-negative individuals). cHCV showed normal precursor frequencies, but increased proportions of memory-phenotype inexperienced cells, as compared to healthy donors or cured HCV patients. These observations could be explained by low surface expression of CD5, a negative regulator of TCR signaling. Accordingly, we demonstrated TCR hyperactivation and generation of potent CD8(+) T cell responses from the altered T cell repertoire of cHCV patients. In sum, we provide the first evidence that naïve CD8(+) T cells are dysregulated during cHCV infection, and establish a new mechanism of immune perturbation secondary to chronic infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.