ArticleeLife2015
Planar cell polarity-mediated induction of neural stem cell expansion during axolotl spinal cord regeneration.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 89 citations in OpenAlex.
- Protocol for non-invasive genotyping of axolotls using skin swabbing.STAR protocols · 2026Article
- Glial cell states bias the regeneration of neuron types across the newt life cycle.bioRxiv : the preprint server for biology · 2026Article
- The endocannabinoid system regulates both ependymoglial and neuronal cell responses to a tail amputation in the axolotl.Developmental dynamics : an official publication of the American Association of Anatomists · 2026Article
- Ependymoglial cells are critical for cortex regeneration in axolotls.Nature communications · 2026Article
- The evolutionary origin and mechanism of chordate tail regeneration. An ancient tale?Cells & development · 2025Review
- Neuronal activation in the axolotl brain promotes tail regeneration.NPJ Regenerative medicine · 2025Article
- How a reaction-diffusion signal can control spinal cord regeneration in axolotls: A modeling study.iScience · 2024Article
- Tail and Spinal Cord Regeneration in Urodelean Amphibians.Life (Basel, Switzerland) · 2024Review
- Planar Cell Polarity Signaling: Coordinated Crosstalk for Cell Orientation.Journal of developmental biology · 2024Review
- Constructing the pharyngula: Connecting the primary axial tissues of the head with the posterior axial tissues of the tail.Cells & development · 2023Review
- Multiscale Asymptotic Analysis Reveals How Cell Growth and Subcellular Compartments Affect Tissue-Scale Hormone Transport.Bulletin of mathematical biology · 2023Article
- A Reproducible Spinal Cord Crush Injury in the Regeneration-Permissive Axolotl.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Distinct signaling signatures drive compensatory proliferation via S-phase acceleration.PLoS genetics · 2022Article
- Spinal cord regeneration - the origins of progenitor cells for functional rebuilding.Current opinion in genetics & development · 2022Review
- Article
- The Role of Tissue Geometry in Spinal Cord Regeneration.Medicina (Kaunas, Lithuania) · 2022Review
- A constitutively expressed fluorescent ubiquitination-based cell-cycle indicator (FUCCI) in axolotls for studying tissue regeneration.Development (Cambridge, England) · 2022Article
- Review
- Regulation of stem cell identity by miR-200a during spinal cord regeneration.Development (Cambridge, England) · 2022Article
- The MAPK Signaling Pathway Presents Novel Molecular Targets for Therapeutic Intervention after Traumatic Spinal Cord Injury: A Comparative Cross-Species Transcriptional Analysis.International journal of molecular sciences · 2021Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Axolotls are uniquely able to mobilize neural stem cells to regenerate all missing regions of the spinal cord. How a neural stem cell under homeostasis converts after injury to a highly regenerative cell remains unknown. Here, we show that during regeneration, axolotl neural stem cells repress neurogenic genes and reactivate a transcriptional program similar to embryonic neuroepithelial cells. This dedifferentiation includes the acquisition of rapid cell cycles, the switch from neurogenic to proliferative divisions, and the re-expression of planar cell polarity (PCP) pathway components. We show that PCP induction is essential to reorient mitotic spindles along the anterior-posterior axis of elongation, and orthogonal to the cell apical-basal axis. Disruption of this property results in premature neurogenesis and halts regeneration. Our findings reveal a key role for PCP in coordinating the morphogenesis of spinal cord outgrowth with the switch from a homeostatic to a regenerative stem cell that restores missing tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.