ArticleeLife2015
Genetic architecture of natural variation in cuticular hydrocarbon composition in Drosophila melanogaster.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
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Who cites it
78 citing papers in PubMed, 156 citations in OpenAlex.
- Closely related ants exhibit species-specific transcriptional responses during temperature acclimation.G3 (Bethesda, Md.) · 2026Article
- Evolutionary basis of male same-sex sexual behavior by multiple pheromone switches in Drosophila.Current biology : CB · 2026Article
- Genetic Basis of Cuticular Hydrocarbon Variation in the Desert AntEcology and evolution · 2026Article
- Lactose-Derived Carbohydrates Induce Sexually Dimorphic Nutritional Programming Effects on Lifespan in Drosophila melanogaster.Aging cell · 2026Article
- Inferring the genetic basis of sleep states inbioRxiv : the preprint server for biology · 2026Article
- Fatty Acid Origin of Insect Pheromones.Advances in experimental medicine and biology · 2026Review
- Genomic Architecture of Nestmate Recognition Cues in the Desert Ant.Ecology and evolution · 2025Article
- Evolutionary basis of intermale sexual behavior by multiple pheromone switches inbioRxiv : the preprint server for biology · 2025Article
- Gene and transposable element expression in response to stress in temperate and tropical populations of Drosophila.Mobile DNA · 2025Article
- Cuticular hydrocarbon profiles in plump bush crickets vary according to species, sex and mating status.Scientific reports · 2025Article
- Regulatory changes in the fatty acid elongase eloF underlie the evolution of sex-specific pheromone profiles in Drosophila prolongata.BMC biology · 2025Article
- On the use of kinship and familiarity associated social information in mediating Drosophila melanogaster oviposition decisions.PloS one · 2025Article
- Testing the genomic overlap between intraspecific mating traits and interspecific mating barriers.Evolution letters · 2024Article
- Cuticular hydrocarbons promote desiccation resistance by preventing transpiration in Drosophila melanogaster.The Journal of experimental biology · 2024Article
- DGRPool, a web tool leveraging harmonizedeLife · 2024Article
- Regulatory Changes in the Fatty Acid ElongasebioRxiv : the preprint server for biology · 2024Article
- The genetic basis of incipient sexual isolation inProceedings. Biological sciences · 2024Article
- Chemical and transcriptomic diversity do not correlate with ascending levels of social complexity in the insect order Blattodea.Ecology and evolution · 2024Article
- Reproductive isolation arises during laboratory adaptation to a novel hot environment.Genome biology · 2024Article
- The genetic basis of variation iniScience · 2024Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Insect cuticular hydrocarbons (CHCs) prevent desiccation and serve as chemical signals that mediate social interactions. Drosophila melanogaster CHCs have been studied extensively, but the genetic basis for individual variation in CHC composition is largely unknown. We quantified variation in CHC profiles in the D. melanogaster Genetic Reference Panel (DGRP) and identified novel CHCs. We used principal component (PC) analysis to extract PCs that explain the majority of CHC variation and identified polymorphisms in or near 305 and 173 genes in females and males, respectively, associated with variation in these PCs. In addition, 17 DGRP lines contain the functional Desat2 allele characteristic of African and Caribbean D. melanogaster females (more 5,9-C27:2 and less 7,11-C27:2, female sex pheromone isomers). Disruption of expression of 24 candidate genes affected CHC composition in at least one sex. These genes are associated with fatty acid metabolism and represent mechanistic targets for individual variation in CHC composition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.