CrossTalk opposing view: Physiological CO2 exchange does not normally depend on membrane channels.

Alzbeta Hulikova, Richard D Vaughan-Jones, Steven A Niederer, Pawel Swietach

Abstract read

In one paragraph

Article in The Journal of physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

Characterization and Computational Engineering of Structural Elements Controlling Gas Permeability in PIP2;1 Aquaporins.Journal of computational chemistry · 2026
Article
Impact of Lipid Composition on Membrane Partitioning and Permeability of Gas Molecules.Membranes · 2026
Article
The HVCN1 voltage-gated proton channel contributes to pH regulation in canine ventricular myocytes.The Journal of physiology · 2022
Article
RNA SEQ Analysis Indicates that the AE3 ClScientific reports · 2017
Article
Rebuttal from Gordon J. Cooper, Rossana Occhipinti and Walter F. Boron.The Journal of physiology · 2015
Article

4 · The record

Corrections and comments

Commented on by
Rebuttal from Gordon J. Cooper, Rossana Occhipinti and Walter F. Boron.2015

5 · Who and what money

Authors and funding

4 authors.

Alzbeta HulikovaBurdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Oxford University, Parks Road, Oxford, OX1 3PT, UK.

Richard D Vaughan-JonesBurdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Oxford University, Parks Road, Oxford, OX1 3PT, UK.

Steven A NiedererBioengineering Department, Division of Imaging Sciences and Biomedical Engineering, King's College London, London, SE1 7EH, UK.

Pawel SwietachBurdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Oxford University, Parks Road, Oxford, OX1 3PT, UK.

Funding

British Heart Foundation PG/12/2/29324British Heart Foundation RG/08/016/26423

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cell Membrane PermeabilityAnimalsCarbon DioxideHumansCarbon Dioxide

Identifiers

PMID26568197

DOI10.1113/JP270013

PMCPMC4666997

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.