ArticleMicrobiome2015
Variable responses of human and non-human primate gut microbiomes to a Western diet.
Article in Microbiome, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed, 147 citations in OpenAlex.
- Translational Development of Microbiome-Based Therapeutics: Kinetics of E. coli Nissle and Engineered Strains in Humans and Nonhuman Primates.Clinical and translational science · 2018Trial
- Healthful plant-based diet, gut enterotype, and cognition in a rural Chinese elderly cohort: A longitudinal multi-omics study.Cell reports. Medicine · 2026Article
- Geophagy in Gibraltar Barbary macaques is a primate tradition anthropogenically induced.Scientific reports · 2026Article
- Shared signatures of alcohol-associated dysbiosis in humans and non-human primates.Current research in microbial sciences · 2026Article
- Gut Microbiota Composition Correlates to Trunk Fat Percentage in Male Cynomolgus Macaque Monkeys.Clinical and translational science · 2025Article
- Age-Dependent Composition and Diversity of the Gut Microbiome in Endangered Gibbon (Microorganisms · 2025Article
- Dietary intake of live microbes mitigates the mortality risk associated with sedentary behavior in US hypertensive individuals.Scientific reports · 2025Article
- AI for rapid identification of major butyrate-producing bacteria in rhesus macaques (Macaca mulatta).Animal microbiome · 2025Article
- Microbial transcriptional responses to host diet maintain gut microbiome homeostasis in the American cockroach.bioRxiv : the preprint server for biology · 2024Article
- Gut microbiome structure and function in asymptomatic diverticulosis.Genome medicine · 2024Article
- Diet components associated with specific bacterial taxa shape overall gut community compositions in omnivorous African viverrids.Ecology and evolution · 2024Article
- Zn(II)-curcumin prevents cadmium-aggravated diabetic nephropathy by regulating gut microbiota and zinc homeostasis.Frontiers in pharmacology · 2024Article
- Significant Microbial Changes Are Evident in the Reproductive Tract of Pregnant Rhesus Monkeys at Mid-Gestation but Their Gut Microbiome Does Not Shift until Late Gestation.Microorganisms · 2023Article
- Methods in Nutrition & Gut Microbiome Research: An American Society for Nutrition Satellite Session [13 October 2022].Nutrients · 2023Article
- Effects of OsomeFood Clean Label plant-based meals on the gut microbiome.BMC microbiology · 2023Article
- Multi-Time-Point Fecal Sampling in Human and Mouse Reveals the Formation of New Homeostasis in Gut Microbiota after Bowel Cleansing.Microorganisms · 2022Article
- Characterizing the Gut Microbiota of Eurasian Otter (Animals : an open access journal from MDPI · 2022Article
- Limited microbiome differences in captive and semi-wild primate populations consuming similar diets.FEMS microbiology ecology · 2022Article
- Effects of gut microbiota-derived extracellular vesicles on obesity and diabetes and their potential modulation through diet.Journal of physiology and biochemistry · 2022Review
- Functional convergence of Yunnan snub-nosed monkey and bamboo-eating panda gut microbiomes revealing the driving by dietary flexibility on mammal gut microbiome.Computational and structural biotechnology journal · 2022Article
Corrections and comments
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Authors and funding
14 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundThe human gut microbiota interacts closely with human diet and physiology. To better understand the mechanisms behind this relationship, gut microbiome research relies on complementing human studies with manipulations of animal models, including non-human primates. However, due to unique aspects of human diet and physiology, it is likely that host-gut microbe interactions operate differently in humans and non-human primates.
resultsHere, we show that the human microbiome reacts differently to a high-protein, high-fat Western diet than that of a model primate, the African green monkey, or vervet (Chlorocebus aethiops sabaeus). Specifically, humans exhibit increased relative abundance of Firmicutes and reduced relative abundance of Prevotella on a Western diet while vervets show the opposite pattern. Predictive metagenomics demonstrate an increased relative abundance of genes associated with carbohydrate metabolism in the microbiome of only humans consuming a Western diet.
conclusionsThese results suggest that the human gut microbiota has unique properties that are a result of changes in human diet and physiology across evolution or that may have contributed to the evolution of human physiology. Therefore, the role of animal models for understanding the relationship between the human gut microbiota and host metabolism must be re-focused.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.