ArticleJournal of orthopaedic surgery and research2015
Heterotopic ossification following hip arthroplasty: a comparative radiographic study about its development with the use of three different kinds of implants.
Article in Journal of orthopaedic surgery and research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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24 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Factors influencing the outcomes of minimally invasive total hip arthroplasty: a systematic review.Journal of orthopaedic surgery and research · 2022Pooled it
- Severe heterotopic ossification after total hip arthroplasty in male patients under 70 years of age: effectiveness of prophylactic protocol.Musculoskeletal surgery · 2025Article
- Pseudotumor in total knee revision arthroplasty resembling heterotopic ossification: A case report.International journal of surgery case reports · 2024Article
- Unipolar Hip Hemiarthroplasty in Geriatric Patients: A Prospective Study and Analysis of Clinical and Radiological Outcomes.Geriatric orthopaedic surgery & rehabilitation · 2024Article
- Clinical and radiological outcomes of an uncemented metaphyseal short stem at minimum 10 years of follow-up: a prospective observational study.Archives of orthopaedic and trauma surgery · 2024Observational
- Heterotopic ossification in primary total hip arthroplasty: risk factor analysis.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2023Article
- Effect of mechanical stimulation on tissue heterotopic ossification: anFrontiers in physiology · 2023Article
- Total hip arthroplasty or hemiarthroplasty for femoral neck fractures in elderly patients with neuromuscular imbalance.Aging clinical and experimental research · 2022Article
- Identification of Risk Factors in the Development of Heterotopic Ossification After Primary Total Hip Arthroplasty.The Journal of clinical endocrinology and metabolism · 2022Article
- Predicting the Poor Clinical and Radiographic Outcomes after the Anatomical Reduction and Internal Fixation of Posterior Wall Acetabular Fractures: A Retrospective Analysis.Journal of clinical medicine · 2022Article
- Are there really specific risk factors for heterotopic ossifications? A case report of 'non-risk factor' after total hip replacement.The Journal of international medical research · 2022Article
- Intervertebral bridging ossification after kyphoplasty in a Parkinson's patient with Kummell's disease: A case report.World journal of clinical cases · 2022Article
- Treatment of Pauwels type III femoral neck fracture with medial femoral neck support screw: a biomechanical and clinical study.Scientific reports · 2021Article
- Heterotopic Ossification after Open Anchor Fixation of the Posterior Cruciate Ligament Avulsion in a Multiligament Injury of the Knee: A Case Report.Journal of orthopaedic case reports · 2021Article
- Critical implication of the PTEN/PI3K/AKT pathway during BMP2-induced heterotopic ossification.Molecular medicine reports · 2021Article
- A Rare Case of Extremely Severe Heterotopic Ossification after Primary Total Hip Arthroplasty due to Persistent Mild Periprosthetic Joint Infection.Case reports in orthopedics · 2021Article
- Heterotopic ossification and clinical results after total hip arthroplasty using the anterior minimally invasive and anterolateral approaches.Archives of medical science : AMS · 2020Article
- Heterotopic Ossification following Total Elbow Arthroplasty in a Patient with Parkinson's Disease: Case Report and Literature Review.Case reports in surgery · 2020Article
- Awareness of Heterotopic Ossification in Total Joint Arthroplasty: A Primer.The Permanente journal · 2020Review
- Size of ischial fibro-ostosis is associated with heterotopic ossification after total hip arthroplasty.International orthopaedics · 2019Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOur purpose was to record the incidence of heterotopic ossification (HO) following hip replacement by different variables to identify patient groups that are likely to develop HO in the absence of a prophylactic protocol.
methodsRadiographically, we studied 651 patients having undergone hip joint replacement, evaluating three kinds of implants: ceramic-ceramic-coupled total hip replacement (THR), TriboFit® with polycarbonate urethane-ceramic coupling and endoprosthesis. Each patient was analysed for HO development by age, gender, diagnosis, presence of previous ossifications, surgical approach and kind of implant. Within the population that developed HO, data were assessed for correlation with severity of ossification graded according to Brooker classification.
resultsThe overall incidence of HOs was 59.91 %. The factors increasing their incidence in the univariate analysis were as follows: lower age of the patients with HO (mean 77.6 years, p = 0.0018) than those subjects who did not develop HO (mean 80.2 years); male gender (64.4 %, p = 0.1011); diagnosis of coxarthrosis (72.7 %, p = 0.0001) compared to femur neck fracture (55.9 %, p = 0.0001); presence of previous HO (76.2 %, p = 0.0260); lateral approach (65.5 %) as opposed to anterior-lateral approach (55.6 %, p = 0.0163); and ceramic-ceramic THR (68.1 %) and TriboFit® (67.0 %) compared to endoprosthesis (51.3 %, p = 0.0001). During multivariate analysis, the presence of HO after previous hip surgery (p = 0.0324) and the kind of implant (p = 0.0004) showed to be independent risk factors for the development of HO. Analysing the population that developed HO, we found that the severity of ossification by Brooker classification was influenced by gender (p = 0.0478) and kind of implant (p = 0.0093).
conclusionsIn agreement with the literature, our radiographic study confirms the following risk factors of HO development in absence of any prophylactic treatment: male gender, diagnosis of coxarthrosis compared to femur neck fracture, previous HO, surgical approach and kind of implant. In particular, Hardinge-Bauer and Watson-Jones surgical approaches, characterized by a wide exposure of the coxofemoral joint, and ceramic-ceramic THR and TriboFit® implants significantly increase the development of HO.
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