Evidence map›Paper›PMID 26567713›Full record

ArticleScientific reports2015

miR-34a screened by miRNA profiling negatively regulates Wnt/β-catenin signaling pathway in Aflatoxin B1 induced hepatotoxicity.

Liye Zhu, Jing Gao, Kunlun Huang, Yunbo Luo, Boyang Zhang, Wentao Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 84 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Liye ZhuLaboratory of Food Safety, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China, 100083.
Jing GaoBeijing Laboratory for Food Quality and Safety, Beijing, P. R. China.
Kunlun HuangLaboratory of Food Safety, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China, 100083.
Yunbo LuoLaboratory of Food Safety, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China, 100083.
Boyang ZhangLaboratory of Food Safety, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China, 100083.
Wentao XuLaboratory of Food Safety, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China, 100083.
China Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aflatoxin-B1 (AFB1), a hepatocarcinogenic mycotoxin, was demonstrated to induce the high rate of hepatocellular carcinoma (HCC). MicroRNAs (miRNAs) participate in the regulation of several biological processes in HCC. However, the function of miRNAs in AFB1-induced HCC has received a little attention. Here, we applied Illumina deep sequencing technology for high-throughout profiling of microRNAs in HepG2 cells lines after treatment with AFB1. Analysis of the differential expression profile of miRNAs in two libraries, we identified 9 known miRNAs and 1 novel miRNA which exhibited abnormal expression. KEGG analysis indicated that predicted target genes of differentially expressed miRNAs are involved in cancer-related pathways. Down-regulated of Drosha, DGCR8 and Dicer 1 indicated an impairment of miRNA biogenesis in response to AFB1. miR-34a was up-regulated significantly, down-regulating the expression of Wnt/β-catenin signaling pathway by target gene β-catenin. Anti-miR-34a can significantly relieved the down-regulated β-catenin and its downstream genes, c-myc and Cyclin D1, and the S-phase arrest in cell cycle induced by AFB1 can also be relieved. These results suggested that AFB1 might down-regulate Wnt/β-catenin signaling pathway in HepG2 cells by up-regulating miR-34a, which may involve in the mechanism of liver tumorigenesis.

Indexed as

Aflatoxin B1beta CateninCarcinoma, HepatocellularCluster AnalysisCyclin D1DEAD-box RNA HelicasesDown-RegulationHep G2 CellsHumansLiver NeoplasmsMicroRNAsOligonucleotides, AntisenseProto-Oncogene Proteins c-mycReal-Time Polymerase Chain ReactionRibonuclease IIIRNA-Binding ProteinsAflatoxin B1beta CateninCyclin D1DEAD-box RNA HelicasesDGCR8 protein, humanDICER1 protein, humanDROSHA protein, humanMicroRNAsMIRN34 microRNA, humanMYC protein, humanOligonucleotides, AntisenseProto-Oncogene Proteins c-mycRibonuclease IIIRNA-Binding ProteinsRNA, Messenger

Identifiers

PMID26567713
PMCPMC4645126
OpenAlexW2401424537

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.