ArticleEnvironmental science & technology2015
Combined LC-MS/MS and Molecular Networking Approach Reveals New Cyanotoxins from the 2014 Cyanobacterial Bloom in Green Lake, Seattle.
Article in Environmental science & technology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- LC-MS/MS Strategy Using Substructure Searching for the Annotation of Cyanopeptide Classes: Implications for New Compound Discovery and Environmental Monitoring.Environmental science & technology · 2026Article
- Molar extinction coefficients, NMR data, and mass spectrometry data provided for Anabaenopeptin A, C, D and Ferintoic Acid A.Data in brief · 2026Article
- Structure-Activity Relationships of Anabaenopeptins as Carboxypeptidase and Phosphatase Inhibitors.ACS chemical biology · 2026Review
- Expanding CyanoHAB Monitoring: New Micropeptins and Generalizable MS/MS Workflows for the Annotation of Cyanopeptide Classes.bioRxiv : the preprint server for biology · 2026Article
- Methodologies for Assessing Chemical Toxicity to Aquatic Microorganisms: A Comparative Review.Molecules (Basel, Switzerland) · 2026Review
- [Advances in molecular networking technology for discovering emerging contaminants and transformation products].Se pu = Chinese journal of chromatography · 2025Review
- Temporal Dynamics of Cyanobacterial Bloom Community Composition and Toxin Production from Urban Lakes.ACS ES&T water · 2024Article
- Spatial and Temporal Resolution of Cyanobacterial Bloom Chemistry Reveals an Open-OceanEnvironmental science & technology · 2024Article
- Article
- Harnessing Cyanobacteria's Bioactive Potential: A Sustainable Strategy for Antioxidant Production.Microorganisms · 2024Article
- Harmful algal bloom aerosols and human health.EBioMedicine · 2023Review
- Metabolomics Reveals Strain-Specific Cyanopeptide Profiles and Their Production Dynamics inToxins · 2023Article
- MS/MS-Based Molecular Networking: An Efficient Approach for Natural Products Dereplication.Molecules (Basel, Switzerland) · 2022Review
- Identification of Novel Microcystins Using High-Resolution MS and MSEnvironmental science & technology · 2022Article
- Anabaenopeptins: What We Know So Far.Toxins · 2021Review
- Monitoring Cyanobacterial Blooms during the COVID-19 Pandemic in Campania, Italy: The Case of Lake Avernus.Toxins · 2021Article
- New Micropeptins with Anti-Neuroinflammatory Activity Isolated from a Cyanobacterial Bloom.ACS omega · 2021Article
- A Mini-Review on Detection Methods of Microcystins.Toxins · 2020Review
- Insight into Unprecedented Diversity of Cyanopeptides in Eutrophic Ponds Using an MS/MS Networking Approach.Toxins · 2020Article
- Article
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Authors and funding
7 authors.
Funding
Abstract
Cyanotoxins obtained from a freshwater cyanobacterial collection at Green Lake, Seattle during a cyanobacterial harmful algal bloom in the summer of 2014 were studied using a new approach based on molecular networking analysis of liquid chromatography tandem mass spectrometry (LC-MS/MS) data. This MS networking approach is particularly well-suited for the detection of new cyanotoxin variants and resulted in the discovery of three new cyclic peptides, namely microcystin-MhtyR (6), which comprised about half of the total microcystin content in the bloom, and ferintoic acids C (12) and D (13). Structure elucidation of 6 was aided by a new microscale methylation procedure. Metagenomic analysis of the bloom using the 16S-ITS rRNA region identified Microcystis aeruginosa as the predominant cyanobacterium in the sample. Fragments of the putative biosynthetic genes for the new cyanotoxins were also identified, and their sequences correlated to the structure of the isolated cyanotoxins.
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