Evidence map›Paper›PMID 26567373›Full record

SynthesisJournal of the American Heart Association2015

Impact of Obstructive Sleep Apnea Syndrome on Endothelial Function, Arterial Stiffening, and Serum Inflammatory Markers: An Updated Meta-analysis and Metaregression of 18 Studies.

Jiayang Wang, Wenyuan Yu, Mingxin Gao, Fan Zhang, Chengxiong Gu, Yang Yu, Yongxiang Wei

Open access · goldAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of the American Heart Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 6 pooled it
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 6 syntheses or guidelines pooled it, 157 citations in OpenAlex.

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  19. Obstructive sleep apnea -related hypertension: a review of the literature and clinical management strategy.Hypertension research : official journal of the Japanese Society of Hypertension · 2024
    Review
  20. Review

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jiayang WangDepartment of Cardiac Surgery, Beijing An Zhen Hospital, Capital Medical University, Beijing, China (J.W., W.Y., M.G., F.Z., C.G., Y.Y.).
Wenyuan YuDepartment of Cardiac Surgery, Beijing An Zhen Hospital, Capital Medical University, Beijing, China (J.W., W.Y., M.G., F.Z., C.G., Y.Y.).
Mingxin GaoDepartment of Cardiac Surgery, Beijing An Zhen Hospital, Capital Medical University, Beijing, China (J.W., W.Y., M.G., F.Z., C.G., Y.Y.).
Fan ZhangDepartment of Cardiac Surgery, Beijing An Zhen Hospital, Capital Medical University, Beijing, China (J.W., W.Y., M.G., F.Z., C.G., Y.Y.).
Chengxiong GuDepartment of Cardiac Surgery, Beijing An Zhen Hospital, Capital Medical University, Beijing, China (J.W., W.Y., M.G., F.Z., C.G., Y.Y.).
Yang YuDepartment of Cardiac Surgery, Beijing An Zhen Hospital, Capital Medical University, Beijing, China (J.W., W.Y., M.G., F.Z., C.G., Y.Y.).
Yongxiang WeiDepartment of Otolaryngology, Beijing An Zhen Hospital, Capital Medical University, Beijing, China (Y.W.).
Beijing Anzhen Hospital · CNCapital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObstructive sleep apnea syndrome (OSAS) has been indicated to contribute to the development of cardiovascular disease; however, the underlying mechanism remains unclear. This study aimed to test the hypothesis that OSAS may be associated with cardiovascular disease by elevating serum levels of inflammatory markers and causing arterial stiffening and endothelial dysfunction. METHODS AND

resultsRelated scientific reports published from January 1, 2006, to June 30, 2015, were searched in the following electronic literature databases: PubMed, Excerpta Medica Database, ISI Web of Science, Directory of Open Access Journals, and the Cochrane Library. The association of OSAS with serum levels of inflammatory markers, endothelial dysfunction, and arterial stiffening were investigated. Overall, 18 eligible articles containing 736 patients with OSAS and 424 healthy persons were included in this meta-analysis. Flow-mediated dilation in patients with moderate-severe OSAS was significantly lower than that in controls (standardized mean difference -1.02, 95% CI -1.31 to -0.73, P<0.0001). Carotid-femoral pulse wave velocity (standardized mean difference 0.45, 95% CI 0.21-0.69, P<0.0001), augmentation index (standardized mean difference 0.57, 95% CI 0.25-0.90, P<0.0001), and serum levels of high-sensitivity C-reactive protein and C-reactive protein (standardized mean difference 0.58, 95% CI 0.42-0.73, P<0.0001) were significantly higher in patients with OSAS than in controls.

conclusionOSAS, particularly moderate-severe OSAS, appeared to reduce endothelial function, increase arterial stiffness, and cause chronic inflammation, leading to the development of cardiovascular disease.

Indexed as

Vascular StiffnessBiomarkersCardiovascular DiseasesCase-Control StudiesC-Reactive ProteinEndothelium, VascularHumansInflammationInflammation MediatorsPrognosisRisk AssessmentRisk FactorsSeverity of Illness IndexSleep Apnea, ObstructiveUp-RegulationVasodilationBiomarkersC-Reactive ProteinInflammation Mediatorsarterial stiffeningC‐reactive proteinendothelial dysfunctionobstructive sleep apnea

Identifiers

PMID26567373
PMCPMC4845236
OpenAlexW2172805160

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.