ArticleApplied and environmental microbiology2016
Host Genetic Control of the Microbiota Mediates the Drosophila Nutritional Phenotype.
Article in Applied and environmental microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
73 citing papers in PubMed, 153 citations in OpenAlex.
- Host genetics and diet jointly shape the microbiome of Drosophila melanogaster but do not predict lifespan or age-related traits.Biogerontology · 2026Article
- Bacterial genome reconstruction and community profiling in Neotropical Drosophila.Scientific reports · 2026Article
- Pro-inflammatory microbiota mediates the effect of host risk genes in Crohn's disease.Frontiers in microbiology · 2026Review
- Age-Dependent Gut Microbiota Dynamics and Their Association with Male Life-History Traits in Drosophila melanogaster.Microbial ecology · 2025Article
- Environment and diet shape the geography-specificApplied and environmental microbiology · 2025Article
- Microbiome composition and co-occurrence dynamics in wildMicrobiology spectrum · 2025Article
- Gut microbiota-mediated lipid accumulation as a driver of evolutionary adaptation to blue light toxicity in Drosophila.Communications biology · 2025Article
- Microbiome evolution plays a secondary role in host rapid adaptation.bioRxiv : the preprint server for biology · 2025Article
- The multifaceted roles of gut microbiota in insect physiology, metabolism, and environmental adaptation: implications for pest management strategies.World journal of microbiology & biotechnology · 2025Review
- Infection with the entomopathogenic nematodes Steinernema alters the Drosophila melanogaster larval microbiome.PloS one · 2025Article
- Covariation Between Microbiome Composition and Host Transcriptome in the Gut of WildEcology and evolution · 2025Article
- DGRPool, a web tool leveraging harmonizedeLife · 2024Article
- A chromosome-level genome assembly of Drosophila madeirensis, a fruit fly species endemic to the island of Madeira.G3 (Bethesda, Md.) · 2024Article
- Selection for stress tolerance and longevity in Drosophila melanogaster have strong impacts on microbiome profiles.Scientific reports · 2024Article
- Article
- Isolation of Enterococcus faecium and determination of its mechanism for promoting the growth and development of Drosophila.Scientific reports · 2023Article
- The influence of the larval microbiome on susceptibility to Zika virus is mosquito genotype-dependent.PLoS pathogens · 2023Article
- Variable microbiomes between mosquito lines are maintained across different environments.PLoS neglected tropical diseases · 2023Article
- The microbial composition of larval airways from Drosophila melanogaster differ between specimens from laboratory and natural habitats.Environmental microbiome · 2023Article
- Gut Microbiome Transplants and Their Health Impacts across Species.Microorganisms · 2023Review
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A wealth of studies has demonstrated that resident microorganisms (microbiota) influence the pattern of nutrient allocation to animal protein and energy stores, but it is unclear how the effects of the microbiota interact with other determinants of animal nutrition, including animal genetic factors and diet. Here, we demonstrate that members of the gut microbiota in Drosophila melanogaster mediate the effect of certain animal genetic determinants on an important nutritional trait, triglyceride (lipid) content. Parallel analysis of the taxonomic composition of the associated bacterial community and host nutritional indices (glucose, glycogen, triglyceride, and protein contents) in multiple Drosophila genotypes revealed significant associations between the abundance of certain microbial taxa, especially Acetobacteraceae and Xanthamonadaceae, and host nutritional phenotype. By a genome-wide association study of Drosophila lines colonized with a defined microbiota, multiple host genes were statistically associated with the abundance of one bacterium, Acetobacter tropicalis. Experiments using mutant Drosophila validated the genetic association evidence and reveal that host genetic control of microbiota abundance affects the nutritional status of the flies. These data indicate that the abundance of the resident microbiota is influenced by host genotype, with consequent effects on nutrient allocation patterns, demonstrating that host genetic control of the microbiome contributes to the genotype-phenotype relationship of the animal host.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.