ArticleNeurology2015
Thalamic amnesia after infarct: The role of the mammillothalamic tract and mediodorsal nucleus.
Article in Neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03867149 (Involvement of the Mediodorsal Nucleus of the Thalamus in Higher Order Cognitive Processes), which is not on this map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Involvement of the Mediodorsal Nucleus of the Thalamus in Higher Order Cognitive Processes : a Study in Patients With a Thalamic Infarct
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- Post-Stroke Working Memory Dysfunction: A Meta-Analysis and Systematic Review.Neuropsychology review · 2021Pooled it
- Electrophysiological Brain Connectivity and Subjective States Evoked by Electrical Stimulation of the Human Mid-thalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Thalamic nuclei insights into Alzheimer's disease.bioRxiv : the preprint server for biology · 2026Article
- Bilateral fornix bodies and posterolateral thalamus ischemia, septum pellucidum cyst.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Standardized methodology for assessing the presence, variants and area of the interthalamic adhesion using anatomical MRI (SNAP-IA): multicentric validation on 565 healthy individuals and multiple neurological disorders.Brain structure & function · 2026Article
- Article
- Posterior Reversible Encephalopathy Syndrome in the Postpartum Period: A Rare Entity With Atypical Presentation.Cureus · 2025Article
- Factors behind poor cognitive outcome following a thalamic stroke.Journal of neurology · 2025Article
- A reappraisal of the role of the mammillothalamic tract in memory deficits following stroke in the thalamus.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- A roadmap towards standardized neuroimaging approaches for human thalamic nuclei.Nature reviews. Neuroscience · 2024Review
- Exploring the impact of the interthalamic adhesion on human cognition: insights from healthy subjects and thalamic stroke patients.Journal of neurology · 2024Article
- Robust thalamic nuclei segmentation from T1-weighted MRI using polynomial intensity transformation.Brain structure & function · 2024Article
- Impairments in the early consolidation of spatial memories via group II mGluR agonism in the mammillary bodies.Scientific reports · 2024Article
- Volumetric brain assessment of long-term head and neck cancer survivors.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2024Article
- Exploring memory-related network via dorsal hippocampus suppression.Network neuroscience (Cambridge, Mass.) · 2024Article
- Characterizing functional modules in the human thalamus: coactivation-based parcellation and systems-level functional decoding.Brain structure & function · 2023Review
- Korsakoff's Syndrome and Alzheimer's Disease-Commonalities and Specificities of Volumetric Brain Alterations within Papez Circuit.Journal of clinical medicine · 2023Article
- Cortico-thalamocortical interactions for learning, memory and decision-making.The Journal of physiology · 2023Review
- The amnestic syndrome of posterior cerebral artery infarction.European journal of neurology · 2022Article
- Article
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Authors and funding
10 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo improve current understanding of the mechanisms behind thalamic amnesia, as it is unclear whether it is directly related to damage to specific nuclei, in particular to the anterior or mediodorsal nuclei, or indirectly related to lesions of the mammillothalamic tract (MTT).
methodsWe recruited 12 patients with a left thalamic infarction and 25 healthy matched controls. All underwent a comprehensive neuropsychological assessment of verbal and visual memory, executive functions, language, and affect, and a high-resolution structural volumetric MRI scan. Thalamic lesions were manually segmented and automatically localized with a computerized thalamic atlas. As well as comparing patients with controls, we divided patients into subgroups with intact or damaged MTT.
resultsOnly one patient had a small lesion of the anterior nucleus. Most of the lesions included the mediodorsal (n = 11) and intralaminar nuclei (n = 12). Patients performed worse than controls on the verbal memory tasks, but the 5 patients with intact MTT who showed isolated lesions of the mediodorsal nucleus (MD) only displayed moderate memory impairment. The 7 patients with a damaged MTT performed worse on the verbal memory tasks than those whose MTT was intact.
conclusionsLesions in the MTT and in the MD result in memory impairment, severely in the case of MTT and to a lesser extent in the case of MD, thus highlighting the roles played by these 2 structures in memory circuits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.