Evidence map›Paper›PMID 26567228›Full record

ArticleHeart (British Cardiac Society)2016

Evidence of microvascular dysfunction in heart failure with preserved ejection fraction.

Joshua F Lee, Zachary Barrett-O'Keefe, Ryan S Garten, Ashley D Nelson, John J Ryan, Jose N Nativi, Russell S Richardson, D Walter Wray

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heart (British Cardiac Society), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 2 pooled it
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 2 syntheses or guidelines pooled it, 120 citations in OpenAlex.

  1. Pooled it
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  12. Incidence of depression in patients with cardiovascular disease and type 2 diabetes: a nationwide cohort study.Clinical research in cardiology : official journal of the German Cardiac Society · 2024
    Article
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  14. Article
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  16. Hypertension and Heart Failure: From Pathophysiology to Treatment.International journal of molecular sciences · 2024
    Review
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  18. Article
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  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Joshua F LeeDepartment of Internal Medicine, University of Utah, Salt Lake City, Utah, USA Geriatric Research, Education, and Clinical Center, VA Medical Center, Salt Lake City, Utah, USA.
Zachary Barrett-O'KeefeGeriatric Research, Education, and Clinical Center, VA Medical Center, Salt Lake City, Utah, USA Department of Exercise & Sport Science, University of Utah, Salt Lake City, Utah, USA.
Ryan S GartenDepartment of Internal Medicine, University of Utah, Salt Lake City, Utah, USA Geriatric Research, Education, and Clinical Center, VA Medical Center, Salt Lake City, Utah, USA.
Ashley D NelsonDepartment of Internal Medicine, University of Utah, Salt Lake City, Utah, USA.
John J RyanDivision of Cardiovascular Medicine, Department of Medicine, University of Utah, Salt Lake City, Utah, USA.
Jose N NativiDivision of Cardiovascular Medicine, Department of Medicine, University of Utah, Salt Lake City, Utah, USA.
Russell S RichardsonDepartment of Internal Medicine, University of Utah, Salt Lake City, Utah, USA Geriatric Research, Education, and Clinical Center, VA Medical Center, Salt Lake City, Utah, USA Department of Exercise & Sport Science, University of Utah, Salt Lake City, Utah, USA.
D Walter WrayDepartment of Internal Medicine, University of Utah, Salt Lake City, Utah, USA Geriatric Research, Education, and Clinical Center, VA Medical Center, Salt Lake City, Utah, USA Department of Exercise & Sport Science, University of Utah, Salt Lake City, Utah, USA.
University of Utah · USLake City VA Medical Center · USGeriatric Research Education and Clinical Center · US

Funding

Tissue Imaging, Biochemistry and MorphologyP01HL091830 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WAGNER, PETER D · 2009 to 2013
$10.1M
Peripheral Vasoconstriction in Heart Failure: Mechanisms & Modulatory InfluencesR01HL118313 · NHLBI · UNIVERSITY OF UTAH · PI WRAY, D. WALTER · 2014 to 2018
$1.9M
Oxidative stress links aging, activity, and mobility limitationI01RX000182 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI RICHARDSON, RUSSELL S. · 2012 to 2014
–
Contribution of Endothelin-1 to Exercise Intolerance in HFI21RX001418 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI WRAY, D. WALTER · 2015 to 2015
–
Rehabilitation for Hypertension: Exercise and Skeletal Muscle Afferent FeedbackI21RX001433 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI RICHARDSON, RUSSELL S. · 2014 to 2015
–
NHLBI NIH HHS P01 HL091830NHLBI NIH HHS R01 HL118313RRD VA I01 RX000182RRD VA I21 RX001418RRD VA I21 RX001433
6 · The paper itself

Abstract

objectiveWhile vascular dysfunction is well defined in patients with heart failure (HF) with reduced ejection fraction (HFrEF), disease-related alterations in the peripheral vasculature of patients with HF with preserved ejection fraction (HFpEF) are not well characterised. Thus, we sought to test the hypothesis that patients with HFpEF would demonstrate reduced vascular function, at the conduit artery and microvascular levels, compared with controls.

methodsWe examined conduit artery function via brachial artery flow-mediated dilation (FMD) and microvascular function via reactive hyperaemia (RH) following 5 min of ischaemia in 24 patients with Class II-IV HFpEF and 24 healthy controls matched for age, sex and brachial artery diameter.

resultsFMD was reduced in patients with HFpEF compared with controls (HFpEF: 3.1±0.7%; CONTROLS: 5.1±0.5%, p=0.03). However, shear rate at time of peak brachial artery dilation was lower in patients with HFpEF compared with controls (HFpEF: 42 070±4018/s; CONTROLS: 69 018±9509/s, p=0.01), and when brachial artery FMD was normalised for the shear stimulus, cumulative area-under-the-curve (AUC) at peak dilation, the between-group differences were eliminated (HFpEF: 0.11±0.03%/AUC; CONTROLS: 0.09±0.01%/AUC, p=0.58). RH, assessed as AUC, was lower in patients with HFpEF (HFpEF: 454±35 mL; CONTROLS: 660±63 mL, p<0.01).

conclusionsCollectively, these data suggest that maladaptations at the microvascular level contribute to the pathophysiology of HFpEF, while conduit artery vascular function is not diminished beyond that which occurs with healthy aging.

Indexed as

MicrocirculationStroke VolumeVasodilationVentricular Function, LeftAgedBlood Flow VelocityBrachial ArteryCase-Control StudiesFemaleHeart FailureHumansHyperemiaMaleRegional Blood FlowUltrasonography, DopplerWalk Test

Identifiers

PMID26567228
PMCPMC4866903
OpenAlexW2179146111

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.