Evidence map›Paper›PMID 26566992›Full record

ArticleJournal of the American Geriatrics Society2015

Methylomic Aging as a Window onto the Influence of Lifestyle: Tobacco and Alcohol Use Alter the Rate of Biological Aging.

Steven R H Beach, Meeshanthini V Dogan, Man-Kit Lei, Carolyn E Cutrona, Meg Gerrard, Frederick X Gibbons, Ronald L Simons, Gene H Brody, Robert A Philibert

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Geriatrics Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 2 syntheses or guidelines pooled it, 98 citations in OpenAlex.

  1. Pooled it
  2. A Systematic Review and Meta-analysis of Environmental, Lifestyle, and Health Factors Associated With DNA Methylation Age.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020
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  11. The Impact of Childhood Mental Health and Substance Use on Methylation Aging Into Adulthood.Journal of the American Academy of Child and Adolescent Psychiatry · 2024
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  17. ResnetAge: A Resnet-Based DNA Methylation Age Prediction Method.Bioengineering (Basel, Switzerland) · 2023
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  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Steven R H BeachDepartment of Psychology, University of Georgia, Athens, Georgia.
Meeshanthini V DoganDepartment of Biomedical Engineering, University of Iowa, Iowa City, Iowa.
Man-Kit LeiCenter for Family Research, University of Georgia, Athens, Georgia.
Carolyn E CutronaDepartment of Psychology, Iowa State University, Ames, Iowa.
Meg GerrardDepartment of Psychology, University of Connecticut, Storrs, Connecticut.
Frederick X GibbonsDepartment of Psychology, University of Connecticut, Storrs, Connecticut.
Ronald L SimonsCenter for Family Research, University of Georgia, Athens, Georgia.
Gene H BrodyCenter for Family Research, University of Georgia, Athens, Georgia.
Robert A PhilibertDepartment of Biomedical Engineering, University of Iowa, Iowa City, Iowa.
University of Georgia · USUniversity of Connecticut · USUniversity of Iowa · USIowa State University · US

Funding

Vulnerability to Drug Use & HIV: Advancing Prevention for Rural African AmericansP30DA027827 · NIDA · UNIVERSITY OF GEORGIA · PI BRODY, GENE H. · 2009 to 2018
$10.2M
The Effects of Smoking on DNA Methylation in Primary Human Lymphocytes.R21DA034457 · NIDA · UNIVERSITY OF IOWA · PI PHILIBERT, ROBERT A · 2012 to 2013
$370k
NIDA NIH HHS P30 DA027827NIDA NIH HHS R21 DA034457
6 · The paper itself

Abstract

objectivesTo examine the effect of the relationship between alcohol and cigarette consumption on biological aging using deoxyribonucleic acid methylation-based indices.

designHierarchical linear regression modeling followed by fitting of higher-order effects.

settingLongitudinal studies of aging and the effect of psychosocial stress.

participantsParticipants in two ethnically informative cohorts (n = 656 white, n = 180 black). MEASUREMENTS: Deviation of biological age from chronological age as a result of smoking and alcohol consumption.

resultsGreater cigarette consumption was associated with accelerated biological aging, with strong effects evident at even low levels of exposure. In contrast, alcohol consumption was associated with a mixed effect on biological aging and pronounced nonlinear effects. At low and heavy levels of alcohol consumption, there was accelerated biological aging, whereas at intermediate levels of consumption there was a relative decelerating effect. The decelerating effects of alcohol were particularly notable at loci for which methylation increased with age.

conclusionThese data support prior epidemiological studies indicating that moderate alcohol use is associated with healthy aging, but we urge caution in interpreting these results. Conversely, smoking has strong negative effects at all levels of consumption. These results also support the use of methylomic indices as a tool for assessing the impact of lifestyle on aging.

Identifiers

PMID26566992
PMCPMC4906951
OpenAlexW2174846980

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.