Evidence map›Paper›PMID 26566970›Full record

ArticleAmerican journal of medical genetics. Part A2016

"This lifetime commitment": Public conceptions of disability and noninvasive prenatal genetic screening.

Rosemary J Steinbach, Megan Allyse, Marsha Michie, Emily Y Liu, Mildred K Cho

Abstract read
In one paragraph

Article in American journal of medical genetics. Part A, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Ethics of Human Genome Editing.Annual review of medicine · 2019
    Review
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rosemary J SteinbachStanford Center for Biomedical Ethics, Stanford, California.
Megan AllyseBiomedical Ethics Research Program and Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota.
Marsha MichieInstitute for Health and Aging, University of California, San Francisco, California.
Emily Y LiuStanford Center for Biomedical Ethics, Stanford, California.
Mildred K ChoStanford Center for Biomedical Ethics, Stanford, California.

Funding

Spectrum Stanford Center for clinical and Translational Research and EducationUL1TR001085 · NCATS · STANFORD UNIVERSITY · PI CULLEN, MARK RICHARD, GREENBERG, HARRY BERNARD · 2013 to 2017
$37.1M
Stanford Center for Clinical and Translational Education and Research (SCCTER)UL1UL1RR025744 · NCRR · STANFORD UNIVERSITY · PI GREENBERG, HARRY BERNARD · 2008 to 2011
$22.4M
Center for Integration of Research on Genetics and EthicsP50HG003389 · NHGRI · STANFORD UNIVERSITY · PI CHO, MILDRED K. · 2004 to 2014
$9.9M
Mapping an ELSI-integrated translational pathway with cell-free fetal DNA testingR00HG006452 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MICHIE, MARSHA MABRY · 2014 to 2016
$747k
NCATS NIH HHS UL1 TR001085NCRR NIH HHS 1 U54 RR024374-01A1NCRR NIH HHS UL1 RR025744NHGRI NIH HHS P50 HG003389NHGRI NIH HHS R00 HG006452
6 · The paper itself

Abstract

Recently, new noninvasive prenatal genetic screening technologies for Down syndrome and other genetic conditions have become commercially available. Unique characteristics of these screening tests have reignited long-standing concerns about prenatal testing for intellectual and developmental disabilities. We conducted a web-based survey of a sample of the US public to examine how attitudes towards disability inform views of prenatal testing in the context of these rapidly advancing prenatal genetic screening technologies. Regardless of opinion toward disability, the majority of respondents supported both the availability of screening and the decision to continue a pregnancy positive for aneuploidy. Individuals rationalized their support with various conceptions of disability; complications of the expressivist argument and other concerns from the disability literature were manifested in many responses analyzed.

Indexed as

Persons with DisabilitiesPublic OpinionAdultAneuploidyAttitude to HealthDown SyndromeFemaleGenetic TestingHumansMalePregnancyPrenatal Diagnosiscell-free DNAdisability rightsdown syndromeintellectual disabilitiesNIPSnoninvasive prenatal screeningprenatal testingpublic opiniontrisomy

Identifiers

PMID26566970
PMCPMC4948186

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.