Evidence map›Paper›PMID 26566771›Full record

ArticleJournal of addictive diseases2016

Risk factors for opioid overdose and awareness of overdose risk among veterans prescribed chronic opioids for addiction or pain.

Christine M Wilder, Shannon C Miller, Elizabeth Tiffany, Theresa Winhusen, Erin L Winstanley, Michael D Stein

Open access · greenAbstract read
In one paragraph

Article in Journal of addictive diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.

  1. Risk Factors for Drug Overdose in Young People: A Systematic Review of the Literature.Journal of child and adolescent psychopharmacology · 2019
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Perceptions of overdose response hotlines and applications among rural and remote individuals who use drugs in Canada: a qualitative study.Health promotion and chronic disease prevention in Canada : research, policy and practice · 2024
    Article
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  8. Review
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  13. Naloxone's role in the national opioid crisis-past struggles, current efforts, and future opportunities.Translational research : the journal of laboratory and clinical medicine · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Christine M Wildera Department of Veterans Affairs Medical Center , Cincinnati , Ohio , USA.
Shannon C Millera Department of Veterans Affairs Medical Center , Cincinnati , Ohio , USA.
Elizabeth Tiffanyb Department of Psychiatry and Behavioral Neuroscience , University of Cincinnati College of Medicine , Cincinnati , Ohio , USA.
Theresa Winhusenb Department of Psychiatry and Behavioral Neuroscience , University of Cincinnati College of Medicine , Cincinnati , Ohio , USA.
Erin L Winstanleyc James L. Winkle College of Pharmacy, University of Cincinnati , Cincinnati , Ohio , USA.
Michael D Steind Department of Medicine , Alpert School of Medicine of Brown University, Butler Hospital , Providence , Rhode Island , USA.
University of Cincinnati Medical Center · USButler Hospital · US

Funding

Advancing Clinical Research Training within Addiction Residency ProgramsR25DA033211 · NIDA · BOSTON MEDICAL CENTER · PI Patrick O'Connor, JEFFREY H. SAMET · 2012 to 2026
$4.2M
MIDCAREER INVESTIGATOR AWARD IN SUBSTANCE ABUSE RESEARCHK24DA000512 · NIDA · RHODE ISLAND HOSPITAL (PROVIDENCE, RI) · PI STEIN, MICHAEL D · 2001 to 2010
$982k
NIDA NIH HHS K24 DA000512NIDA NIH HHS K24 DA00512NIDA NIH HHS R25 DA033211NIDA NIH HHS R25DA033211
6 · The paper itself

Abstract

Rising overdose fatalities among U.S. veterans suggest veterans taking prescription opioids may be at risk for overdose. However, it is unclear whether veterans prescribed chronic opioids are aware of this risk. The objective of this study was to identify risk factors and determine awareness of risk for opioid overdose in veterans treated with opioids for chronic pain, using veterans treated with methadone or buprenorphine for opioid use disorder as a high-risk comparator group. In the current study, 90 veterans on chronic opioid medication, for either opioid use disorder or pain management, completed a questionnaire assessing risk factors, knowledge, and self-estimate of risk for overdose. Nearly all veterans in both groups had multiple overdose risk factors, although individuals in the pain management group had on average a significantly lower total number of risk factors than did individuals in the opioid use disorder group (5.9 versus 8.5, p < .0001). On average, participants treated for pain management scored slightly but significantly lower on knowledge of opioid overdose risk factors (12.1 versus 13.5, p < .01). About 70% of participants, regardless of group, believed their overdose risk was below that of the average American adult. There was no significant relationship between self-estimate of overdose risk and either number or knowledge of opioid overdose risk factors. Our results suggest that veterans in both groups underestimated their risk for opioid overdose. Expansion of overdose education to include individuals on chronic opioids for pain management and a shift in educational approaches to overdose prevention may be indicated.

Indexed as

AdultAgedAnalgesics, OpioidBehavior, AddictiveBuprenorphineChronic PainDrug OverdoseFemaleHumansMaleMethadoneMiddle AgedMidwestern United StatesOpioid-Related DisordersPain ManagementPrescription DrugsAnalgesics, OpioidBuprenorphineMethadonePrescription Drugschronic painmedication-assisted treatmentopioidsOverdoserisk assessmentveterans

Identifiers

PMID26566771
PMCPMC4751580
OpenAlexW2243129027

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.