ArticleJournal of the American Geriatrics Society2015
The Prognostic Importance of Frailty in Cancer Survivors.
Article in Journal of the American Geriatrics Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Effect of Home- and Community-Based Physical Activity Interventions on Physical Function Among Cancer Survivors: A Systematic Review and Meta-Analysis.Archives of physical medicine and rehabilitation · 2017Pooled it
- The effect of qigong on frailty in older cancer survivors: a randomised controlled trial.Age and ageing · 2025Trial
- Using an electronic frailty index and patient reported outcomes to predict sarcopenia risk.Scientific reports · 2025Article
- The association between social vulnerability index and survival in older adults with gastrointestinal cancers - The CARE Registry.Journal of geriatric oncology · 2025Article
- Pain and Frailty in Childhood Cancer Survivors: A Narrative Review.Current oncology (Toronto, Ont.) · 2024Review
- Frailty in patients with ovarian cancer and the role of healthcare access, race, and ethnicity.Gynecologic oncology · 2024Article
- High cotinine levels as an associated factor with frailty status in older adults: evidence from the NHANES study.BMC geriatrics · 2024Article
- Association of frailty with mortality in cancer survivors: results from NHANES 1999-2018.Scientific reports · 2024Article
- Assessing Frailty in Gastrointestinal Cancer: Two Diseases in One?Current oncology reports · 2024Review
- Frailty Among Breast Cancer Survivors: Evidence From Swedish Population Data.American journal of epidemiology · 2023Article
- Frailty in chronic myeloid leukemia: evidence from 2016-2018 Nationwide Inpatient Sample of the US.BMC geriatrics · 2023Article
- Association of frailty with the incidence risk of cardiovascular disease and type 2 diabetes mellitus in long-term cancer survivors: a prospective cohort study.BMC medicine · 2023Article
- Frailty and medical financial hardship among older adults with cancer in the United States.Frontiers in oncology · 2023Article
- Do Cancer and Cancer Treatments Accelerate Aging?Current oncology reports · 2022Review
- Dietary Supplements in People with Metastatic Cancer Who Are Experiencing Malnutrition, Cachexia, Sarcopenia, and Frailty: A Scoping Review.Nutrients · 2022Article
- Social Justice and Equity: Why Older Adults With Cancer Belong-A Life Course Perspective.American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting · 2022Article
- When Eating Becomes Torturous: Understanding Nutrition-Related Cancer Treatment Side Effects among Individuals with Cancer and Their Caregivers.Nutrients · 2022Article
- Neuropsychiatric Disorders and Frailty in Older Adults over the Spectrum of Cancer: A Narrative Review.Cancers · 2022Review
- Coping during COVID-19: a mixed methods study of older cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Commentary: Eurolung score as a predictor of long-term survival: It is not all about the tumor.The Journal of thoracic and cardiovascular surgery · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo quantify the prognostic importance of prefrailty and frailty in a population-based sample of cancer survivors.
designThe Third National Health and Nutrition Examination Survey mortality-linked prospective cohort study.
settingEighty-nine survey locations across the United States.
participantsPopulation-based sample of older adults (average age 72.2) with a self-reported diagnosis of non-skin-related cancer (N = 416). MEASUREMENTS: The primary outcome was all-cause mortality. Frailty components included low weight for height, slow walking, weakness, exhaustion, and low physical activity. Participants with none of the five criteria were classified as nonfrail, those with one or two as prefrail, and those with three or more as frail.
resultsThe prevalence of prefrailty was 37.3% and of frailty was 9.1%. During a median follow-up of 11.2 years, 319 (76.7%) participants died. Median survival was 13.9 years for participants classified as nonfrail, 9.5 years for those classified as prefrail, and 2.5 years for those classified as frail. Cancer survivors classified as prefrail (hazard ratio (HR) = 1.84, 95% confidence interval (CI) = 1.28-2.65, P = .001) or frail (HR = 2.79, 95% CI = 1.34-5.81, P = .006) had a higher risk of premature mortality than those classified as nonfrail.
conclusionPrefrailty and frailty are prevalent clinical syndromes that may confer greater risk of premature mortality in older adult cancer survivors. Identifying frail cancer survivors and targeting interventions for them may be a strategy to improve survival after cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.