ArticleAutophagy2015
Disruption of microtubules in plants suppresses macroautophagy and triggers starch excess-associated chloroplast autophagy.
Article in Autophagy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)Autophagy · 2021Guideline
- Unleash the dogs of death: metacaspase 5, microtubules, and hypersensitive response.Plant cell reports · 2025Article
- Systemic and Phloem-Specific Protein Targeting by High Affinity Nanobodies Expressed From a Plant RNA Virus Vector.Molecular plant pathology · 2025Article
- A tissue-specific rescue strategy reveals the local roles of autophagy in leaves and seeds for resource allocation.Plant physiology · 2024Article
- 14-3-3 proteins inhibit autophagy by regulating SINAT-mediated proteolysis of ATG6 in Arabidopsis.BMC plant biology · 2024Article
- Autophagy formation, microtubule disorientation, and alteration of ATG8 and tubulin gene expression under simulated microgravity in Arabidopsis thaliana.NPJ microgravity · 2024Article
- Studying plant autophagy: challenges and recommended methodologies.Advanced biotechnology · 2023Review
- Methanolic Extracts ofInternational journal of molecular sciences · 2023Article
- A conserved microtubule-binding region in Xanthomonas XopL is indispensable for induced plant cell death reactions.PLoS pathogens · 2023Article
- Autophagic degradation of membrane-bound organelles in plants.Bioscience reports · 2023Review
- An Overview of the Molecular Mechanisms and Functions of Autophagic Pathways in Plants.Plant signaling & behavior · 2021Article
- Turnip mosaic virus P1 suppresses JA biosynthesis by degrading cpSRP54 that delivers AOCs onto the thylakoid membrane to facilitate viral infection.PLoS pathogens · 2021Article
- New insights into AtNBR1 as a selective autophagy cargo receptor in Arabidopsis.Plant signaling & behavior · 2021Article
- Cocktail Therapy of Fosthiazate and Cupric-Ammoniun Complex for Citrus Huanglongbing.Frontiers in plant science · 2021Article
- Actin filaments are dispensable for bulk autophagy in plants.Autophagy · 2019Article
- Plant AtEH/Pan1 proteins drive autophagosome formation at ER-PM contact sites with actin and endocytic machinery.Nature communications · 2019Article
- Interaction between Brassica yellows virus silencing suppressor P0 and plant SKP1 facilitates stability of P0 in vivo against degradation by proteasome and autophagy pathways.The New phytologist · 2019Article
- Increased Autophagy of Rice Can Increase Yield and Nitrogen Use Efficiency (NUE).Frontiers in plant science · 2019Article
- Battlefield Cytoskeleton: Turning the Tide on Plant Immunity.Molecular plant-microbe interactions : MPMI · 2019Review
- A computational framework for cortical microtubule dynamics in realistically shaped plant cells.PLoS computational biology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microtubules, the major components of cytoskeleton, are involved in various fundamental biological processes in plants. Recent studies in mammalian cells have revealed the importance of microtubule cytoskeleton in autophagy. However, little is known about the roles of microtubules in plant autophagy. Here, we found that ATG6 interacts with TUB8/β-tubulin 8 and colocalizes with microtubules in Nicotiana benthamiana. Disruption of microtubules by either silencing of tubulin genes or treatment with microtubule-depolymerizing agents in N. benthamiana reduces autophagosome formation during upregulation of nocturnal or oxidation-induced macroautophagy. Furthermore, a blockage of leaf starch degradation occurred in microtubule-disrupted cells and triggered a distinct ATG6-, ATG5- and ATG7-independent autophagic pathway termed starch excess-associated chloroplast autophagy (SEX chlorophagy) for clearance of dysfunctional chloroplasts. Our findings reveal that an intact microtubule network is important for efficient macroautophagy and leaf starch degradation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.