ArticleAmerican journal of physiology. Heart and circulatory physiology2016
Augmented pressor and sympathetic responses to skeletal muscle metaboreflex activation in type 2 diabetes patients.
Article in American journal of physiology. Heart and circulatory physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 92 citations in OpenAlex.
- Cardiorespiratory responses to muscle metaboreflex activation in fibrosing interstitial lung disease.Experimental physiology · 2022Trial
- Combined respiratory muscle training and photobiomodulation improve systemic and tissue-specific redox homeostasis in a rat model of type 2 diabetes.Acta diabetologica · 2026Article
- Inflammation, mechanical allodynia and an exaggerated exercise pressor reflex during disease progression in UCD-type 2 diabetes mellitus rats.Experimental physiology · 2026Article
- Interleukin-1 type 1 receptor blockade attenuates the exaggerated exercise pressor reflex in male UC Davis type 2 diabetic mellitus rats.The Journal of physiology · 2025Article
- Intracerebroventricular insulin injection acutely normalizes the augmented exercise pressor reflex in male rats with type 2 diabetes mellitus.The Journal of physiology · 2025Article
- Blood pressure levels are higher in individuals with type 1 diabetes mellitus compared to healthy subjects during exercise stress test.Scientific reports · 2025Article
- Sympathetic reactivity to emotional stress in women with major depressive disorder.Autonomic neuroscience : basic & clinical · 2025Article
- Maintained sympathetic reactivity but blunted pressor response to static handgrip exercise in heart failure with preserved ejection fraction.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Abnormal cardiovascular control during exercise: Role of insulin resistance in the brain.Autonomic neuroscience : basic & clinical · 2025Review
- Blockade of insulin receptor signaling in the medullary cardiovascular centers impairs open-loop arterial baroreflex function via attenuated neural arc in healthy male rats.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Independent influence of type 2 diabetes on reduced cardiopulmonary fitness in patients after percutaneous coronary intervention: a cross-sectional study.Scientific reports · 2025Article
- Sympathetic and blood pressure reactivity in young adults with major depressive disorder.Journal of affective disorders · 2024Article
- Hemodynamic responses to the cold pressor test in individuals with metabolic syndrome: a case-control study in a multiracial sample of adults.Journal of human hypertension · 2024Article
- Respiratory modulation of sympathetic transduction to blood pressure in health and type 2 diabetes.The Journal of physiology · 2024Article
- Cyclooxygenase products contribute to the exaggerated exercise pressor reflex evoked by static muscle contraction in male UCD-type 2 diabetes mellitus rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Glucose metabolism and autonomic function in healthy individuals and patients with type 2 diabetes mellitus at rest and during exercise.Experimental physiology · 2024Article
- Fat-free mass is associated with exercise pressor responses, but not cold pressor responses, in humans: influence of maximal voluntary contraction.Frontiers in sports and active living · 2024Article
- Sympathetic transduction at rest and during cold pressor test in young healthy non-Hispanic Black and White women.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Operational Modal Analysis of Near-Infrared Spectroscopy Measure of 2-Month Exercise Intervention Effects in Sedentary Older Adults with Diabetes and Cognitive Impairment.Brain sciences · 2023Article
- Cardiovascular responses to static handgrip exercise and postexercise ischemia in heart failure with preserved ejection fraction.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Previous studies have reported exaggerated increases in arterial blood pressure during exercise in type 2 diabetes (T2D) patients. However, little is known regarding the underlying neural mechanism(s) involved. We hypothesized that T2D patients would exhibit an augmented muscle metaboreflex activation and this contributes to greater pressor and sympathetic responses during exercise. Mean arterial pressure (MAP), heart rate (HR), and muscle sympathetic nerve activity (MSNA) were measured in 16 patients with T2D (8 normotensive and 8 hypertensive) and 10 healthy controls. Graded isolation of the muscle metaboreflex was achieved by postexercise ischemia (PEI) following static handgrip performed at 30% and 40% maximal voluntary contraction (MVC). A cold pressor test (CPT) was also performed as a generalized sympathoexcitatory stimulus. Increases in MAP and MSNA during 30 and 40% MVC handgrip were augmented in T2D patients compared with controls (P < 0.05), and these differences were maintained during PEI (MAP: 30% MVC PEI: T2D, Δ16 ± 2 mmHg vs. controls, Δ8 ± 1 mmHg; 40% MVC PEI: T2D, Δ26 ± 3 mmHg vs. controls, Δ16 ± 2 mmHg, both P < 0.05). MAP and MSNA responses to handgrip and PEI were not different between normotensive and hypertensive T2D patients (P > 0.05). Interestingly, MSNA responses were also greater in T2D patients compared with controls during the CPT (P < 0.05). Collectively, these findings indicate that muscle metaboreflex activation is augmented in T2D patients and this contributes, in part, to augmented pressor and sympathetic responses to exercise in this patient group. Greater CPT responses suggest that a heightened central sympathetic reactivity may be involved.
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