ReviewWorld journal of clinical pediatrics2015
Acute encephalitis and encephalopathy associated with human parvovirus B19 infection in children.
Review in World journal of clinical pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Human parvovirus B19-associated Guillain-Barré syndrome diagnosed by cerebrospinal fluid targeted next-generation sequencing: a case report and literature review.BMC infectious diseases · 2026Review
- Review
- Article
- Parvovirus B19 infection in children: a comprehensive review of clinical manifestations and management.Italian journal of pediatrics · 2024Review
- Parvovirus B19-Induced Lower Motor Neuron Facial Nerve Palsy and Cutaneous Small-Vessel Vasculitis: A Case Report.Cureus · 2024Article
- Neurological Impact of Respiratory Viruses: Insights into Glial Cell Responses in the Central Nervous System.Microorganisms · 2024Review
- Fever, Seizures, and Basal Ganglia Lesions.Clinical pediatrics · 2024Article
- Review
- Rubella virus chronic inflammatory disease and other unusual viral phenotypes in inborn errors of immunity.Immunological reviews · 2024Review
- Encephalopathy Caused by Human Parvovirus B19 Genotype 1 Associated withCurrent issues in molecular biology · 2023Article
- Identification and Genomic Characterization of Parvovirus B19V Genotype 3 Viruses from Cases of Meningoencephalitis in West Bengal, India.Microbiology spectrum · 2022Article
- Human parvovirus B19 infection in hospitalized patients suspected of infection with pathogenic microorganism.Frontiers in cellular and infection microbiology · 2022Article
- GABAA receptor encephalitis associated with human parvovirus B19 virus infection: Case report.Medicine · 2021Article
- Parvovirus-induced encephalitis in a juvenile raccoon.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2021Article
- Acute Necrotizing Encephalopathy of Childhood Associated with Human Parvovirus B19 Infection.Indian journal of pediatrics · 2020Article
- Central Nervous System Virus Infection in African Children with Cerebral Malaria.The American journal of tropical medicine and hygiene · 2020Article
- Human Parvoviruses May Affect the Development and Clinical Course of Meningitis and Meningoencephalitis.Brain sciences · 2020Article
- Viruses in unexplained encephalitis cases in American black bears (Ursus americanus).PloS one · 2020Article
- Evidence of Human Parvovirus B19 Infection in the Post-Mortem Brain Tissue of the Elderly.Viruses · 2018Article
- Clinical impact & pathogenic mechanisms of human parvovirus B19: A multiorgan disease inflictor incognito.The Indian journal of medical research · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reports of neurologic manifestations of human parvovirus B19 (B19) infection have been on the rise. Acute encephalitis and encephalopathy is the most common, accounting for 38.8% of total B19-associated neurological manifestations. To date, 34 children with B19 encephalitis and encephalopathy have been reported, which includes 21 encephalitis and 13 encephalopathy cases. Ten (29%) were immunocompromised and 17 (39%) had underlying diseases. Fever at the onset of disease and rash presented in 44.1% and 20.6% of patients, respectively. Neurological manifestations include alteration of consciousness occurred in all patients, seizures in 15 (44.1%) patients, and focal neurologic signs in 12 (35.3%) patients. Anemia and pleocytosis in cerebrospinal fluid (CSF) occurred in 56.3% and 48.1% of patients, respectively. Serum Anti-B19 IgM (82.6%) and CSF B19 DNA (90%) were positive in the majority of cases. Some patients were treated with intravenous immunoglobulins and/or steroids, although an accurate evaluation of the efficacy of these treatment modalities cannot be determined. Nineteen (57.6%) patients recovered completely, 11 (33.3%) patients had some neurological sequelae and 3 (8.8%) patients died. Although the precise pathogenesis underlying the development of B19 encephalitis and encephalopathy is unclear, direct B19 infection or NS1protein of B19 toxicity in the brain, and immune-mediated brain injuries have been proposed.
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