ReviewWorld journal of clinical pediatrics2015
Hirschsprung's disease: Historical notes and pathological diagnosis on the occasion of the 100(th) anniversary of Dr. Harald Hirschsprung's death.
Review in World journal of clinical pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Perioperative outcomes in primary neonatal pullthrough versus pullthrough in older children with Hirschsprung disease: a systematic review and meta-analysis.Scientific reports · 2026Pooled it
- Adult Onset Hirschsprung's Disease With Overlapping Presentation of Sigmoid Volvulus: Two Case Reports With Literature Review at Tikur Ambessa Specialized Hospital, AAU, Ethiopia.Clinical case reports · 2026Article
- Article
- A note on the history of Hirschsprung's disease, and an over 120 years apology.Pediatric surgery international · 2025Article
- Histopathologic Concerns and Diagnostic Challenges in Hirschsprung's Disease: An Eastern European Single-Center Observational Study.Life (Basel, Switzerland) · 2025Article
- History of surgery for Hirschsprung disease: a view from Melbourne.World journal of pediatric surgery · 2025Article
- A new systematization of histological analysis for the diagnosis of Hirschsprung's disease.Clinics (Sao Paulo, Brazil) · 2023Article
- Editorial: Hirschsprung disease: genetic susceptibility, disease mechanisms and innovative management in the multi-omics era.Frontiers in pediatrics · 2023Article
- Human Pluripotent Stem Cell-Based Models for Hirschsprung Disease: From 2-D Cell to 3-D Organoid Model.Cells · 2022Review
- Adult Hirschsprung disease as acute intestinal obstruction: a case report.The Pan African medical journal · 2022Article
- LncRNA-RMST Functions as a Transcriptional Co-regulator of SOX2 to Regulate miR-1251 in the Progression of Hirschsprung's Disease.Frontiers in pediatrics · 2022Article
- Hirschsprung disease and more: dysregulation of ERBB2 and ERBB3.The Journal of clinical investigation · 2021Article
- Reoperative techniques and management in Hirschsprung disease: a narrative review.Translational gastroenterology and hepatology · 2021Review
- Hirschsprung's Disease-Recent Understanding of Embryonic Aspects, Etiopathogenesis and Future Treatment Avenues.Medicina (Kaunas, Lithuania) · 2020Review
- Article
- Efficacy of Sox10 Promoter Methylation in the Diagnosis of Intestinal Neuronal Dysplasia From the Peripheral Blood.Clinical and translational gastroenterology · 2019Article
- Congenital intestinal stenosis and Hirschsprung's disease: two extremely rare pathologies in a newborn puppy.BMC veterinary research · 2019Article
- A rare case of rectal prolapse after Deloyers procedure in a patient with Hirschsprung's disease: A case report.International journal of surgery case reports · 2019Article
- Functional Studies on NovelFrontiers in genetics · 2019Article
- Genome-wide association study of Hirschsprung disease detects a novel low-frequency variant at the RET locus.European journal of human genetics : EJHG · 2018Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hirschsprung's disease (HSCR) or congenital megacolon is one of the differential diagnoses of chronic constipation mostly in infancy and may indeed represent a challenge for pediatricians, pediatric surgeons, and pediatric pathologists. The diagnosis relies clearly on the identification of the absence of ganglion cells at the plexuses (submucosus and myentericus) of the bowel wall. HSCR is usually located at the terminal (distal) rectum with potential pre-terminal or proximal extension to the less distal large bowel (sigmoid colon). Astonishingly, there is some evidence that Hindu surgeons of prehistoric India may have been exposed and had considerable knowledge about HSCR, but this disease is notoriously and eponymously named to Dr. Harald Hirschsprung (1830-1916), who brilliantly presented two infants with fatal constipation at the Berlin conference of the German Society of Pediatrics more than one century ago. Historical milestones and diagnosis of HSCR (originally called "Die Hirschsprungsche Krankheit") are reviewed. More than 100 years following his meticulous and broad description, HSCR is still a puzzling disease for both diagnosis and treatment. HSCR remains a critical area of clinical pediatrics and pediatric surgery and an intense area of investigation for both molecular and developmental biologists.
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