ArticleProgress in biomaterials
PEG-penetrated chitosan-alginate co-polysaccharide-based partially and fully cross-linked hydrogels as ECM mimic for tissue engineering applications.
Article in Progress in biomaterials. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- Mesenchymal Stem Cell-Laden Nanofibril-Reinforced Injectable and Self-Healing Alginate Dialdehyde/Gelatin Hydrogels with Enhanced Mechanical and Chondrogenic Performance In Vitro.Macromolecular bioscience · 2026Article
- Dual-Self-Crosslinking Effect of Alginate-Di-Aldehyde with Natural and Synthetic Co-Polymers as Injectable In Situ-Forming Biodegradable Hydrogel.Gels (Basel, Switzerland) · 2024Article
- A Gellan Gum, Polyethylene Glycol, Hydroxyapatite Composite Scaffold with the Addition of Ginseng Derived Compound K with Possible Applications in Bone Regeneration.Gels (Basel, Switzerland) · 2024Article
- Reasoning on Pore Terminology in 3D Bioprinting.Gels (Basel, Switzerland) · 2024Review
- Recent Advances in Marine Biomaterials Tailored and Primed for the Treatment of Damaged Soft Tissues.Marine drugs · 2023Review
- Article
- Antimicrobial effects of hydroxyapatite mosaicked polyvinyl alcohol-alginate semi-interpenetrating hydrogel-loaded with ethanolic extract of Glycyrrhiza glabra against oral pathogens.Progress in biomaterials · 2022Article
- Influence of Charge and Heat on the Mechanical Properties of Scaffolds from Ionic Complexation of Chitosan and Carboxymethyl Cellulose.ACS biomaterials science & engineering · 2021Article
- Alginate Microencapsulation for Three-Dimensional In Vitro Cell Culture.ACS biomaterials science & engineering · 2021Review
- PPAR-Gamma as putative gene target involved in Butein mediated anti-diabetic effect.Molecular biology reports · 2020Article
- Enzymatically degradable alginate hydrogel systems to deliver endothelial progenitor cells for potential revasculature applications.Biomaterials · 2018Article
- Cellulose-based hydrogel materials: chemistry, properties and their prospective applications.Progress in biomaterials · 2018Review
- Blow-spun chitosan/PEG/PLGA nanofibers as a novel tissue engineering scaffold with antibacterial properties.Journal of materials science. Materials in medicine · 2016Article
- Improving the Growth Rate of Human Adipose-Derived Mesenchymal Stem Cells in Alginate/Gelatin Versus Alginate Hydrogels.Iranian journal of biotechnology · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The emerging strategy of tissue engineering for the management of end-stage organ failure and associated complications mainly relies on ECM mimicking scaffolds for neo-tissue genesis. In the current study, novel polyethylene glycol interpenetrated cross-linked hydrogel scaffold based on a co-polysaccharide (PIAC) synthesized from two marine heteropolysaccharides, alginate and chitosan, was designed. Partially cross-linked (PIAC-P) and fully cross-linked hydrogels (PIAC-F) were prepared. The physiochemical evaluations of both the hydrogels revealed the presence of alginate fraction and extensive -OH groups on the surface, sufficient water content and water holding capacity. The porosity and bulk density were also appreciable. The scaffolds were hemocompatible and were able to adsorb appreciable plasma proteins on to the surface. MTT assay on hydrogel extracts and direct contact assay showed the nontoxic effects of fibroblast cells upon contact with the hydrogel. Live/dead assay using ethidium bromide/acridine orange cocktail on fibroblast cells grown on the hydrogels after 5 days of initial seeding displayed green nucleus revealing the non-apoptotic cells. PIAC-P hydrogels were superior to certain aspects due to the availability of free functional groups than PIAC-F where most of these groups were utilized for cross-linking. The biological evaluations confirmed the healthy being and 3D growth of fibroblasts on the porous networks of both the hydrogels. The present hydrogel can form an ECM mimic and can form a potent candidate for various tissue engineering applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.