ReviewWorld journal of gastrointestinal endoscopy2015
Pancreatic insulinomas: Laparoscopic management.
Review in World journal of gastrointestinal endoscopy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Six-Year Outcomes Following Stereotactic Body Radiation Therapy for Insulinoma: A Case Report and Literature Review.Cureus · 2025Article
- Review
- Diagnosis and management of benign secreting pancreatic insulinoma: What's new? 4 case report.Rare tumors · 2025Article
- Initial Application of Fluorescence Imaging for Intraoperative Localization of Small Neuroendocrine Tumors in the Pancreas: Case Report and Review of the Literature.Journal of gastrointestinal cancer · 2024Review
- Pioneering robotic-assisted surgery for insulinoma during pregnancy: The first case report and literature review.Heliyon · 2024Article
- Article
- Retrospective study of 20 cats surgically treated for insulinoma.Veterinary surgery : VS · 2023Article
- Insulinoma-Accurate Preoperative Localization Is the Key to Management: An Initial Experience.Indian journal of surgical oncology · 2022Article
- Single-incision laparoscopic enucleation for pancreatic insulinoma with preoperative nasopancreatic stent placement: A case report.International journal of surgery case reports · 2022Article
- Surgery of pancreas tumors in pediatric and adolescent patients: a single institution experience in South America.Pediatric surgery international · 2021Article
- Preoperative stenting in insulinoma located nearby pancreatic duct: a case report and literature review.Journal of surgical case reports · 2021Article
- Clinical application of ultrasound-guided mediastinal lymph node biopsy through cervical mediastinoscopy.Thoracic cancer · 2021Article
- Hyperinsulinemic hypoglycemia in children and adolescents: Recent advances in understanding of pathophysiology and management.Reviews in endocrine & metabolic disorders · 2020Review
- The functioning side of the pancreas: a review on insulinomas.Journal of endocrinological investigation · 2020Review
- Treatment of Insulinomas by Laparoscopic Radiofrequency Ablation: Case Reports and Literature Review.Open medicine (Warsaw, Poland) · 2020Article
- Short-term and long-term outcomes after robot-assisted versus laparoscopic distal pancreatectomy for pancreatic neuroendocrine tumors (pNETs): a multicenter comparative study.Langenbeck's archives of surgery · 2019Article
- Minimally Invasive Versus Open Treatment for Benign Sporadic Insulinoma Comparison of Short-Term and Long-Term Outcomes.World journal of surgery · 2018Article
- Minimally invasive distal pancreatectomy for PNETs: laparoscopic or robotic approach?Oncotarget · 2017Article
- Spontaneous hypoglycemia: diagnostic evaluation and management.Endocrine · 2016Article
- Insulinoma After Bariatric Surgery: Diagnostic Dilemma and Therapeutic Approaches.Obesity surgery · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insulinomas are rare pancreatic neuroendocrine tumors that are most commonly benign, solitary, and intrapancreatic. Uncontrolled insulin overproduction from the tumor produces neurological and adrenergic symptoms of hypoglycemia. Biochemical diagnosis is confirmed by the presence of Whipple's triad, along with corroborating measurements of blood glucose, insulin, proinsulin, C-peptide, β-hydroxybutyrate, and negative tests for hypoglycemic agents during a supervised fasting period. This is accompanied by accurate preoperative localization using both invasive and non-invasive imaging modalities. Following this, careful preoperative planning is required, with the ensuing procedure being preferably carried out laparoscopically. An integral part of the laparoscopic approach is the application of laparoscopic intraoperative ultrasound, which is indispensable for accurate intraoperative localization of the lesion in the pancreatic region. The extent of laparoscopic resection is dependent on preoperative and intraoperative findings, but most commonly involves tumor enucleation or distal pancreatectomy. When performed in an experienced surgical unit, laparoscopic resection is associated with minimal mortality and excellent long-term cure rates. Furthermore, this approach confers equivalent safety and efficacy rates to open resection, while improving cosmesis and reducing hospital stay. As such, laparoscopic resection should be considered in all cases of benign insulinoma where adequate surgical expertise is available.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.