ArticleJournal of Korean medical science2015
Necrotizing Enterocolitis among Very-Low-Birth-Weight Infants in Korea.
Article in Journal of Korean medical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Global incidence of Necrotizing Enterocolitis: a systematic review and Meta-analysis.BMC pediatrics · 2020Pooled it
- Risk factors for necrotizing enterocolitis in neonates: a systematic review of prognostic studies.BMC pediatrics · 2017Pooled it
- Obstetric and Neonatal Outcomes Following Immediate Delivery Versus Expectant Management in Pregnant Women With Preterm Premature Rupture of Membranes During the Late Preterm Period in Korea.Journal of Korean medical science · 2026Article
- Risk factors associated with the development of necrotizing enterocolitis in preterm infants on an exclusive human milk diet: a single-center case-control study.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Increased incidence of necrotizing enterocolitis in very/extremely preterm infants with early hypotension: a retrospective cohort study.Translational pediatrics · 2025Article
- Differentially expressed genes in the placentas with pre-eclampsia and fetal growth restriction using RNA sequencing and verification.Journal of perinatal medicine · 2025Article
- Umbilical arterial catheter duration as risk factor for Bell's Stage III necrotizing enterocolitis in preterm neonates.JPGN reports · 2024Article
- Do hematological biomarkers predict surgical necrotizing enterocolitis?Pediatric research · 2024Article
- Development of artificial neural networks for early prediction of intestinal perforation in preterm infants.Scientific reports · 2022Article
- Necrotizing Enterocolitis and Its Predictors Among Preterm Neonates Admitted in Neonatal Intensive Care Units of Gurage Zone Public Hospitals, Southwest Ethiopia, 2021.Pediatric health, medicine and therapeutics · 2022Article
- Incidence of necrotizing enterocolitis in South Korea from 2007 to 2017.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Clinical characteristic comparison of low birth weight and very low birth weight preterm infants with neonatal necrotizing enterocolitis: a single tertiary center experience from eastern China.Pediatric surgery international · 2018Article
- Neonatal independent predictors of severe NEC.Pediatric surgery international · 2018Article
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency and remains a major cause of mortality for very-low-birth-weight infants (VLBWI) requiring surgery. To date, there have been no large-scale studies evaluating the incidence, associated clinical factors and outcomes of NEC for VLBWI in Korea. The 2,326 VLBWI of a total 2,386 Korean Neonatal Network (KNN) cohort born with a birth weight below 1,500 g between January 2013 to June 2014 were included in this analysis. The overall incidence of NEC (stage ≥ 2) among VLBWI in Korea was 6.8%; 149 infants had NEC stage ≥ 2 and 2,177 infants did not have NEC. Surgery was performed for 77 (53%) of the infants in the NEC group. NEC was related to lower gestational age (GA) and birth weight (P < 0.001). Multivariate logistic regression analysis demonstrated that NEC was consistently related to hypotension within one week after birth (OR 2.0, 95% CI 1.0-3.9). With respect to outcome, the NEC group had longer times to reach 100 mL/kg/day feeding (P < 0.001), longer TPN duration (P < 0.001) and hospitalization (P = 0.031) and higher PVL (P < 0.001) and mortality rate (P < 0.001). When the medical and surgical NEC groups were compared, GA was significantly lower and PDA was more found in the surgical NEC group. The overall incidence of NEC in Korea is similar to that of other multicenter studies. In addition to GA and birth weight, hypotension within a week of life is significantly related to NEC.
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