ArticleJournal of clinical biochemistry and nutrition2015
Changes in arterial stiffness and nitric oxide production with Chlorella-derived multicomponent supplementation in middle-aged and older individuals.
Article in Journal of clinical biochemistry and nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Beneficial effects of Chlorella species supplementation in the general population: a GRADE-assessed systematic review and dose-response meta-analysis.Nutrition & diabetes · 2026Pooled it
- Edible Algae Reduce Blood Pressure in Humans: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2025Pooled it
- Quantifying the Effect of Supplementation with Algae and Its Extracts on Glycolipid Metabolism: A Meta-Analysis of Randomized Controlled Trials.Nutrients · 2020Pooled it
- Trial
- Effects ofInternational journal of environmental research and public health · 2020Trial
- Effects of Marine-Derived Components on Cardiovascular Disease Risk Factors and Gut Microbiota Diversity.Marine drugs · 2024Review
- Combined Aerobic Exercise Training andNutrients · 2024Article
- Bioactivity of Macronutrients fromNutrients · 2023Review
- Biotechnological Approaches for Biomass and Lipid Production Using MicroalgaeJournal of microbiology and biotechnology · 2022Review
- TetraSODNutrients · 2022Article
- Algae Supplementation for Exercise Performance: Current Perspectives and Future Directions for Spirulina and Chlorella.Frontiers in nutrition · 2022Article
- Edible Microalgae and Their Bioactive Compounds in the Prevention and Treatment of Metabolic Alterations.Nutrients · 2021Review
- Potential ofNutrients · 2020Review
- Combined aerobic and low-intensity resistance exercise training increases basal nitric oxide production and decreases arterial stiffness in healthy older adults.Journal of clinical biochemistry and nutrition · 2020Article
- Nitric Oxide and Decreases in Resistance Exercise Blood Pressure With Aerobic Exercise Training in Older Individuals.Frontiers in physiology · 2019Article
- Microvascular endothelial function in Japanese early adolescents.Journal of clinical biochemistry and nutrition · 2017Article
- Effect ofJournal of clinical biochemistry and nutrition · 2017Article
- Changes in salivary flow rate following Chlorella-derived multicomponent supplementation.Journal of clinical biochemistry and nutrition · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chlorella is a unicellular green alga, which contains a variety of nutrients including amino acids, dietary fibers, n-3 unsaturated fatty acid, vitamins, and minerals. We previously demonstrated that Chlorella-derived multicomponent supplementation decreases arterial stiffness in young men. However, mechanisms underlying the reduction in arterial stiffness by Chlorella-derived supplementation and the effect in middle-aged and older individuals have remained unexplored. This study tested our hypothesis that Chlorella-derived supplementation improves arterial stiffness via an increase in nitric oxide (NO, a endothelium-derived relaxing factor) production in middle-aged and older individuals. Thirty-two subjects between 45 and 75 years of age assigned to placebo and Chlorella groups in a double-blinded manner and took respective tablets for 4 weeks. Before and after the supplementations, brachial-ankle pulse wave velocity (baPWV, an index of arterial stiffness) and plasma nitrite/nitrate (NOx, end product of NO) concentration were measured. There was no difference in baPWV between before and after the placebo intake, but baPWV decreased after the Chlorella supplementation. Changes in baPWV with the Chlorella supplementation were correlated with those in plasma NOx concentration. We concluded that Chlorella-derived multicomponent supplementation decreases arterial stiffness in middle-aged and older individuals. It may be associated with increase in NO production by vascular endothelium.
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