ArticleAutophagy2015
Autophagy contributes to regulation of the hypoxia response during submergence in Arabidopsis thaliana.
Article in Autophagy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.
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Who cites it
95 citing papers in PubMed, 191 citations in OpenAlex.
- Autophagy-phytohormone crosstalk: a dual-regulation axis in plant development.Frontiers in plant science · 2026Review
- Combined hormonomic, transcriptomic, and metabolomic analyses reveal the role of programmed cell death in bud abscission of Chinese chestnut (Frontiers in plant science · 2026Article
- Interaction Between CsATG8f and CsRAP2.12 Modulates Antioxidant Defense and Hypoxia Response During Submergence inInternational journal of molecular sciences · 2025Article
- From Model to Crop: Roles of Macroautophagy inGenes · 2025Review
- An A. thaliana mutant lacking all nine ATG8 isoforms provides genetic evidence for functional specialization of ATG8 in plants.Journal of cell science · 2025Article
- Arabidopsis MACP2 contributes to autophagy induction by modulating starvation-induced reactive oxygen species homeostasis.Advanced biotechnology · 2025Article
- Autophagy deficiency confers freezing tolerance in Arabidopsis thaliana.BMC plant biology · 2025Article
- Analysis of Autophagy Under Abiotic Stress in Arabidopsis Seedlings Expressing the GFP-ATG8 Autophagosome Marker.Current protocols · 2025Article
- Can autophagy enhance crop resilience to environmental stress?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- The basal level of salicylic acid represses the PRT6 N-degron pathway to modulate root growth and stress response in rice.Plant communications · 2025Article
- Metabolic strategies in hypoxic plants.Plant physiology · 2024Review
- 14-3-3 proteins inhibit autophagy by regulating SINAT-mediated proteolysis of ATG6 in Arabidopsis.BMC plant biology · 2024Article
- The calcium-dependent protein kinase CPK16 regulates hypoxia-induced ROS production by phosphorylating the NADPH oxidase RBOHD in Arabidopsis.The Plant cell · 2024Article
- Superoxide signalling and antioxidant processing in the plant nucleus.Journal of experimental botany · 2024Review
- Full-length transcriptome sequencing of Arabidopsis plants provided new insights into the autophagic regulation of photosynthesis.Scientific reports · 2024Article
- Acetylation modification in the regulation of macroautophagy.Advanced biotechnology · 2024Review
- NBR1-mediated selective autophagy of ARF7 modulates root branching.EMBO reports · 2024Article
- Autophagic Regulation of Adipogenesis Through TP53INP2: Insights from In Silico and In Vitro Analysis.Molecular biotechnology · 2024Article
- Cathepsin B degrades RbcL during freezing-induced programmed cell death in Arabidopsis.Plant cell reports · 2024Article
- Autophagy: A New Avenue and Biochemical Mechanisms to Mitigate the Climate Change.Scientifica · 2024Review
35 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autophagy involves massive degradation of intracellular components and functions as a conserved system that helps cells to adapt to adverse conditions. In mammals, hypoxia rapidly stimulates autophagy as a cell survival response. Here, we examine the function of autophagy in the regulation of the plant response to submergence, an abiotic stress that leads to hypoxia and anaerobic respiration in plant cells. In Arabidopsis thaliana, submergence induces the transcription of autophagy-related (ATG) genes and the formation of autophagosomes. Consistent with this, the autophagy-defective (atg) mutants are hypersensitive to submergence stress and treatment with ethanol, the end product of anaerobic respiration. Upon submergence, the atg mutants have increased levels of transcripts of anaerobic respiration genes (alcohol dehydrogenase 1, ADH1 and pyruvate decarboxylase 1, PDC1), but reduced levels of transcripts of other hypoxia- and ethylene-responsive genes. Both submergence and ethanol treatments induce the accumulation of reactive oxygen species (ROS) in the rosettes of atg mutants more than in the wild type. Moreover, the production of ROS by the nicotinamide adenine dinucleotide phosphate (NADPH) oxidases is necessary for plant tolerance to submergence and ethanol, submergence-induced expression of ADH1 and PDC1, and activation of autophagy. The submergence- and ethanol-sensitive phenotypes in the atg mutants depend on a complete salicylic acid (SA) signaling pathway. Together, our findings demonstrate that submergence-induced autophagy functions in the hypoxia response in Arabidopsis by modulating SA-mediated cellular homeostasis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.