Evidence map›Paper›PMID 26566126›Full record

ArticlePloS one2015

Genetic Variation in the Catechol-O-Methyl Transferase Val108/158Met Is Linked to the Caudate and Posterior Cingulate Cortex Volume in Healthy Subjects: Voxel-Based Morphometry Analysis of Brain Magnetic Resonance Imaging.

Keita Watanabe, Shingo Kakeda, Reiji Yoshimura, Satoru Ide, Kenji Hayashi, Asuka Katsuki, Wakako Umene-Nakano, Rieko Watanabe, Osamu Abe, Yukunori Korogi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Keita WatanabeDepartment of Radiology, University of Occupational and Environmental Health, Fukuoka, Japan.
Shingo KakedaDepartment of Radiology, University of Occupational and Environmental Health, Fukuoka, Japan.
Reiji YoshimuraDepartment of Psychiatry, University of Occupational and Environmental Health, Fukuoka, Japan.
Satoru IdeDepartment of Radiology, University of Occupational and Environmental Health, Fukuoka, Japan.
Kenji HayashiDepartment of Psychiatry, University of Occupational and Environmental Health, Fukuoka, Japan.
Asuka KatsukiDepartment of Psychiatry, University of Occupational and Environmental Health, Fukuoka, Japan.
Wakako Umene-NakanoDepartment of Psychiatry, University of Occupational and Environmental Health, Fukuoka, Japan.
Rieko WatanabeDepartment of Radiology, University of Occupational and Environmental Health, Fukuoka, Japan.
Osamu AbeDepartment of Radiology, Nihon University School of Medicine, Tokyo, Japan.
Yukunori KorogiDepartment of Radiology, Nihon University School of Medicine, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effect of the catechol-O-methyltransferase (COMT) Val158Met polymorphism on brain morphology has been investigated but remains controversial. We hypothesized that a comparison between Val/Val and Val/Met individuals, which may represent the most different combinations concerning the effects of the COMT genotype, may reveal new findings. We investigated the brain morphology using 3-Tesla magnetic resonance imaging in 27 Val/Val and 22 Val/Met individuals. Voxel-based morphometry revealed that the volumes of the bilateral caudate and posterior cingulate cortex were significantly smaller in Val/Val individuals than in Val/Met individuals [right caudate: false discovery rate (FDR)-corrected p = 0.048; left caudate: FDR-corrected p = 0.048; and bilateral posterior cingulate cortex: FDR-corrected p = 0.048]. This study demonstrates that interacting functional variants of COMT affect gray matter regional volumes in healthy subjects.

Indexed as

Polymorphism, Single NucleotideAdultAgedCatechol O-MethyltransferaseCaudate NucleusDopamineFalse Positive ReactionsFemaleGenotypeGray MatterGyrus CinguliHealthy VolunteersHumansLinear ModelsMagnetic Resonance ImagingMaleCatechol O-MethyltransferaseCOMT protein, humanDopamineMethionineValine

Identifiers

PMID26566126
PMCPMC4643939

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.